Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 May 30;10(6):294.
doi: 10.3390/v10060294.

The Interplay of Viral and Host Factors in Chikungunya Virus Infection: Targets for Antiviral Strategies

Kai Zhi Wong  1 , Justin Jang Hann Chu  2   3
Affiliations
Review

The Interplay of Viral and Host Factors in Chikungunya Virus Infection: Targets for Antiviral Strategies

Kai Zhi Wong et al. Viruses. .

Abstract

Chikungunya virus (CHIKV) has re-emerged as one of the many medically important arboviruses that have spread rampantly across the world in the past decade. Infected patients come down with acute fever and rashes, and a portion of them suffer from both acute and chronic arthralgia. Currently, there are no targeted therapeutics against this debilitating virus. One approach to develop potential therapeutics is by understanding the viral-host interactions. However, to date, there has been limited research undertaken in this area. In this review, we attempt to briefly describe and update the functions of the different CHIKV proteins and their respective interacting host partners. In addition, we also survey the literature for other reported host factors and pathways involved during CHIKV infection. There is a pressing need for an in-depth understanding of the interaction between the host environment and CHIKV in order to generate potential therapeutics.

Keywords: antiviral; chikungunya virus; host factors; interactions; potential therapeutics; viral non-structural proteins; viral structural proteins.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Silva L.A., Dermody T.S. Chikungunya virus: Epidemiology, replication, disease mechanisms, and prospective intervention strategies. J. Clin. Investig. 2017;127:737–749. doi: 10.1172/JCI84417. - DOI - PMC - PubMed
    1. Waggoner J.J., Pinsky B.A. How Great is the Threat of Chikungunya Virus? Expert Rev. Anti Infect. Ther. 2015;13:291–293. doi: 10.1586/14787210.2015.995634. - DOI - PMC - PubMed
    1. Sreekumar E., Issac A., Nair S., Hariharan R., Janki M.B., Arathy D.S., Regu R., Mathew T., Anoop M., Niyas K.P., et al. Genetic characterization of 2006–2008 isolates of Chikungunya virus from Kerala, South India, by whole genome sequence analysis. Virus Genes. 2010;40:14–27. doi: 10.1007/s11262-009-0411-9. - DOI - PMC - PubMed
    1. Robinson M.C. An epidemic of virus disease in Southern Province, Tanganyika Territory, in 1952–1953. Trans. R. Soc. Trop. Med. Hyg. 1957;51:238–240. doi: 10.1016/0035-9203(55)90080-8. - DOI - PubMed
    1. Powers A.M., Brault A.C., Tesh R.B., Weaver S.C. Re-emergence of chikungunya and o’nyong-nyong viruses: Evidence for distinct geographical lineages and distant evolutionary relationships. J. Gen. Virol. 2000;81:471–479. doi: 10.1099/0022-1317-81-2-471. - DOI - PubMed

Publication types

Substances

LinkOut - more resources