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Review
. 2018 Aug 21:38:273-301.
doi: 10.1146/annurev-nutr-082117-051644. Epub 2018 May 23.

Nutritional Regulation of Intestinal Stem Cells

Salvador Alonso  1   2   3 , Ömer H Yilmaz  2   4
Affiliations
Review

Nutritional Regulation of Intestinal Stem Cells

Salvador Alonso et al. Annu Rev Nutr. .

Abstract

Dietary composition and calorie intake are major determinants of health and disease. Calorie restriction promotes metabolic changes that favor tissue regeneration and is arguably the most successful and best-conserved antiaging intervention. Obesity, in contrast, impairs tissue homeostasis and is a major risk factor for the development of diseases including cancer. Stem cells, the central mediators of tissue regeneration, integrate dietary and energy cues via nutrient-sensing pathways to maintain growth or respond to stress. We discuss emerging data on the effects of diet and nutrient-sensing pathways on intestinal stem cells, as well as their potential application in the development of regenerative and therapeutic interventions.

Keywords: calorie restriction; cancer; fasting; high-fat diet; intestinal stem cells.

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