Steps Toward Understanding Mitochondrial Fe/S Cluster Biogenesis
- PMID: 29746243
- DOI: 10.1016/bs.mie.2017.09.004
Steps Toward Understanding Mitochondrial Fe/S Cluster Biogenesis
Abstract
Iron-sulfur clusters (Fe/S clusters) are essential cofactors required throughout the clades of biology for performing a myriad of unique functions including nitrogen fixation, ribosome assembly, DNA repair, mitochondrial respiration, and metabolite catabolism. Although Fe/S clusters can be synthesized in vitro and transferred to a client protein without enzymatic assistance, biology has evolved intricate mechanisms to assemble and transfer Fe/S clusters within the cellular environment. In eukaryotes, the foundation of all cellular clusters starts within the mitochondria. The focus of this review is to detail the mitochondrial Fe/S biogenesis (ISC) pathway along with the Fe/S cluster transfer steps necessary to mature Fe/S proteins. New advances in our understanding of the mitochondrial Fe/S biogenesis machinery will be highlighted. Additionally, we will address various experimental approaches that have been successful in the identification and characterization of components of the ISC pathway.
Keywords: Acyl carrier protein; ISU; Iron–sulfur clusters; Mitochondria; Nfu1.
© 2018 Elsevier Inc. All rights reserved.
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