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Review
. 2018 Feb 25;35(1):145-150.
doi: 10.7507/1001-5515.201705077.

[The application of nanotopography in the development of tissue engineered tissues using mesenchymal stem cells]

[Article in Chinese]
Weiying Fang  1 , Tingyu Gu  2 , Yi Liu  2 , Lan Xu  2 , Yuelei Chen  2
Affiliations
Review

[The application of nanotopography in the development of tissue engineered tissues using mesenchymal stem cells]

[Article in Chinese]
Weiying Fang et al. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. .

Abstract
in English, Chinese

Tissue engineering has emerged as a promising approach for the repair and functional reconstruction of damaged tissues. The bionic and intelligentized scaffolds provide the structural support for cell growth and differentiation as well as tissue regeneration. The surface properties of the biological material implant, the nanotopology in particular, become key aspects in determining the success of the implant. Mesenchymal stem cells (MSC) are widely favored by researchers as the seed cells in tissue engineering. Recently, it has been shown that nanotopographical characteristics of biomaterials regulate a wide range of MSC properties from their cellular behavior and differentiation potential. Herein, this review will provide an update on studies investigating the roles of nanotopography in the development of tissue engineering using MSC.

组织工程被认为是未来针对工程化组织缺损进行修复及功能性重建的有效手段之一。仿生生物支架为种子细胞的增殖分化和组织再生提供了理想的支持与空间，而这些支架的表面特性特别是表面纳米拓扑结构成为决定植入能否成功的关键。间充质干细胞（MSC）被公认为理想的组织工程种子细胞，而纳米拓扑结构可以调节 MSC 的细胞行为和分化潜能。本文综述了近年来纳米拓扑结构在 MSC 构建工程化组织中的应用与发展。.

Keywords: mesenchymal stem cell; nanotechnology; nanotopography; tissue engineering.

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Figures

图 1
图 1
Three basic nanotopography geometries 三种典型的纳米拓扑结构
See this image and copyright information in PMC

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References

    1. Jiang Weicheng, Cheng Yuhao, Yen M H, et al Cryo-chemical decellularization of the whole liver for mesenchymal stem cells-based functional hepatic tissue engineering. Biomaterials. 2014;35(11):3607–3617. - PMC - PubMed
    1. Yang Lei, Liu Haipei, Lin Yuan Biomaterial nanotopography-mediated cell responses: experiment and modeling. Int J Smart Nano Mater. 2015;5(4):227–256.
    1. Chen Weiqiang, Shao Yue, Li Xiang, et al Nanotopographical surfaces for stem cell fate control: Engineering mechanobiology from the Bottom. Nano Today. 2014;9(6):759–784. - PMC - PubMed
    1. Ao Chenghong, Niu Yan, Zhang Ximu, et al Fabrication and characterization of electrospun cellulose/nano-hydroxyapatite nanofibers for bone tissue engineering. Int J Biol Macromol. 2017;97:568–573. - PubMed
    1. Shahnavazi M, Ketabi M A, Fekrazad R, et al Fabrication of Chitosan-nano hydroxyapatite scaffold for dental tissue engineering. Key Eng Mater. 2017;720:223–227.

Grants and funding

国家自然科学基金项目（81470862）；中国科学院战略生物资源服务网络计划项目（ZSSB-003，CZBZX-1）

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