The Lysosome, Elixir of Neural Stem Cell Youth

doi:10.1016/j.stem.2018.04.017

Comment

. 2018 May 3;22(5):619-620.

doi: 10.1016/j.stem.2018.04.017.

The Lysosome, Elixir of Neural Stem Cell Youth

Milos S Simic¹, Andrew Dillin²

Affiliations

¹ Glenn Center for Research on Aging, Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
² Glenn Center for Research on Aging, Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA. Electronic address: dillin@berkeley.edu.

PMID: 29727677
DOI: 10.1016/j.stem.2018.04.017

Free article

Comment

The Lysosome, Elixir of Neural Stem Cell Youth

Milos S Simic et al. Cell Stem Cell. 2018.

Free article

. 2018 May 3;22(5):619-620.

doi: 10.1016/j.stem.2018.04.017.

Authors

Milos S Simic¹, Andrew Dillin²

Affiliations

¹ Glenn Center for Research on Aging, Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
² Glenn Center for Research on Aging, Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA. Electronic address: dillin@berkeley.edu.

PMID: 29727677
DOI: 10.1016/j.stem.2018.04.017

Abstract

Recently in Science, Leeman et al. find that perturbing lysosomal activity of quiescent NSCs directly impedes their ability to become activated, similar to what happens during aging. Excitingly, they could rejuvenate old quiescent NSCs by enhancing the lysosome pathway, ameliorating their ability to clear protein aggregates and become activated.

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Lysosome activation clears aggregates and enhances quiescent neural stem cell activation during aging.
Leeman DS, Hebestreit K, Ruetz T, Webb AE, McKay A, Pollina EA, Dulken BW, Zhao X, Yeo RW, Ho TT, Mahmoudi S, Devarajan K, Passegué E, Rando TA, Frydman J, Brunet A. Leeman DS, et al. Science. 2018 Mar 16;359(6381):1277-1283. doi: 10.1126/science.aag3048. Epub 2018 Mar 15. Science. 2018. PMID: 29590078 Free PMC article.

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Huang J, Meng P, Wang C, Zhang Y, Zhou L. Huang J, et al. Theranostics. 2022 Feb 28;12(5):2445-2464. doi: 10.7150/thno.70588. eCollection 2022. Theranostics. 2022. PMID: 35265219 Free PMC article. Review.

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The Lysosome, Elixir of Neural Stem Cell Youth

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The Lysosome, Elixir of Neural Stem Cell Youth

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