Aspects of cytokine induced modulation of immunity and inflammation with emphasis on interleukin 1
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- PMID: 2969245
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Aspects of cytokine induced modulation of immunity and inflammation with emphasis on interleukin 1
Arzneimittelforschung.
1988 Mar.
Abstract
Interleukin 1 (IL 1) contributes to both acute and chronic inflammatory processes. Purified IL 1 by itself is only one of the signals that induces local inflammation. The contribution of IL 1 to local inflammatory reactions is influenced by exogenous stimuli, antagonists such as steroid hormones and TGF beta (tissue growth factor beta) and agonists such as TNF (tissue necrosis factor). IL 1 production is depressed by glucocorticoids, but glucocorticoids induce expression of receptors for IL 1 on selected cell types including B lymphocytes and fibroblasts. Thus, complex interactions between hormones and cytokines modulate immunological and inflammatory responses.
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