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Review
. 2018 Sep;12(5):e1700142.
doi: 10.1002/prca.201700142. Epub 2018 May 21.

Proteomic Analysis of Exosomes and Its Application in HIV-1 Infection

Collins Cheruiyot  1 , Zemplen Pataki  1 , Bharat Ramratnam  1   2   3 , Ming Li  1
Affiliations
Review

Proteomic Analysis of Exosomes and Its Application in HIV-1 Infection

Collins Cheruiyot et al. Proteomics Clin Appl. 2018 Sep.

Abstract

Exosomes are 30-100 nm extracellular vesicles secreted from late endosomes by various types of cells. Numerous studies have suggested that exosomes play significant roles in human immunodeficiency virus 1 (HIV-1) biogenesis. Proteomics coupled with exosome fractionation has been successfully used to identify various exosomal proteins and helped to uncover the interactions between exosomes and HIV-1. To inform the current progress in the intersection of exosome, proteomics, and HIV-1, this review is focused on: i) analyzing different exosome isolation, purification methods, and their implications in HIV-1 studies; ii) evaluating the roles of various proteomic techniques in defining exosomal contents; iii) discussing the research and clinical applications of proteomics and exosome in HIV-1 biology.

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