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Review
. 2018 Mar 30;9(24):17171-17180.
doi: 10.18632/oncotarget.24660.

Head and neck squamous cell carcinoma and its correlation with human papillomavirus in people living with HIV: a systematic review

Manuela Ceccarelli  1 , Emmanuele Venanzi Rullo  1 , Alessio Facciolà  1 , Giordano Madeddu  2 , Bruno Cacopardo  3 , Rosaria Taibi  4 , Francesco D'Aleo  1 , Marilia Rita Pinzone  5 , Isa Picerno  6 , Michele di Rosa  7 , Giuseppa Visalli  6 , Fabrizio Condorelli  8 , Giuseppe Nunnari  1 , Giovanni Francesco Pellicanò  9
Affiliations
Review

Head and neck squamous cell carcinoma and its correlation with human papillomavirus in people living with HIV: a systematic review

Manuela Ceccarelli et al. Oncotarget. .

Abstract

Over the last 20 years we assisted to an increase in the mean age of People Living with HIV and their comorbidities. Especially, there was an increase in Human Papillomavirus-related head and neck squamous cell carcinomas. Despite their increasing incidence in HIV-positive people, mechanisms that lead to their development and progression are only partially understood. The aim of this review is to identify key data and factors about HPV-related head and neck squamous cell carcinoma in HIV-seropositive patients. Systematic search and review of the relevant literature-peer-reviewed and grey-was conducted using the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines. We included in our review only the 35 full-text articles we considered the most substantial. It is mandatory to improve our knowledge about the interactions existing between HPV and HIV, and about their actions on oral mucosa immune system.

Keywords: HIV; HNSCC; HPV; head and neck cancer; papillomavirus.

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Conflict of interest statement

CONFLICTS OF INTEREST The authors declare that they have no conflicts of interests.

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