Prevention and Treatment of Type 2 Diabetes: A Pathophysiological-Based Approach

doi:10.1016/j.tem.2018.03.014

Review

. 2018 Jun;29(6):370-379.

doi: 10.1016/j.tem.2018.03.014. Epub 2018 Apr 14.

Prevention and Treatment of Type 2 Diabetes: A Pathophysiological-Based Approach

Dorit Samocha-Bonet¹, Sophie Debs², Jerry R Greenfield³

Affiliations

¹ Diabetes and Metabolism Division, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia; St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Sydney, NSW 2010, Australia. Electronic address: d.samochabonet@garvan.org.au.
² Diabetes and Metabolism Division, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia.
³ Diabetes and Metabolism Division, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia; St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Sydney, NSW 2010, Australia; Department of Endocrinology and Diabetes Services, St Vincent's Hospital, Sydney, NSW 2010, Australia.

PMID: 29665986
DOI: 10.1016/j.tem.2018.03.014

Review

Prevention and Treatment of Type 2 Diabetes: A Pathophysiological-Based Approach

Dorit Samocha-Bonet et al. Trends Endocrinol Metab. 2018 Jun.

. 2018 Jun;29(6):370-379.

doi: 10.1016/j.tem.2018.03.014. Epub 2018 Apr 14.

Authors

Dorit Samocha-Bonet¹, Sophie Debs², Jerry R Greenfield³

Affiliations

¹ Diabetes and Metabolism Division, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia; St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Sydney, NSW 2010, Australia. Electronic address: d.samochabonet@garvan.org.au.
² Diabetes and Metabolism Division, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia.
³ Diabetes and Metabolism Division, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia; St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Sydney, NSW 2010, Australia; Department of Endocrinology and Diabetes Services, St Vincent's Hospital, Sydney, NSW 2010, Australia.

PMID: 29665986
DOI: 10.1016/j.tem.2018.03.014

Abstract

Prediabetes affects approximately 40% of American adults. Randomized trials report that a proportion of individuals with prediabetes develop diabetes despite caloric restriction, physical activity, and/or when treated with metformin, the first-line medication for patients with type 2 diabetes mellitus (T2DM). Currently, there are no valid predictors of the effectiveness of these measures in determining who will and who will not progress to the T2DM state. Few studies have examined the clinical and phenotypic predictors of better and worse glycemic response to lifestyle interventions and metformin in prediabetes and diabetes. Further studies incorporating 'omic' approaches to discover novel markers of phenotypes and treatment effectiveness may pave the way to personalizing the treatment of prediabetes and diabetes.

Keywords: genomics; gut microbiomics; metabolomics; metformin; personalized management; prediabetes.

PubMed Disclaimer

Cited by

Progression from prediabetes to type 2 diabetes mellitus induced by overnutrition.
Zhang Y, Shen T, Wang S. Zhang Y, et al. Hormones (Athens). 2022 Dec;21(4):591-597. doi: 10.1007/s42000-022-00399-2. Epub 2022 Oct 5. Hormones (Athens). 2022. PMID: 36197636 Review.
Rationale and design of a randomised controlled trial testing the effect of personalised diet in individuals with pre-diabetes or type 2 diabetes mellitus treated with metformin.
Htet TD, Godneva A, Liu Z, Chalmers E, Kolobkov D, Snaith JR, Richens R, Toth K, Danta M, Hng TM, Elinav E, Segal E, Greenfield JR, Samocha-Bonet D. Htet TD, et al. BMJ Open. 2020 Oct 10;10(10):e037859. doi: 10.1136/bmjopen-2020-037859. BMJ Open. 2020. PMID: 33040003 Free PMC article. Clinical Trial.
Lonicerae Japonicae Flos extract and chlorogenic acid attenuates high-fat-diet- induced prediabetes via CTRPs-AdipoRs-AMPK/PPARα axes.
Guo C, Zhang X, Yu Y, Wu Y, Xie L, Chang C. Guo C, et al. Front Nutr. 2022 Oct 14;9:1007679. doi: 10.3389/fnut.2022.1007679. eCollection 2022. Front Nutr. 2022. PMID: 36313074 Free PMC article.
Reducing postprandial glucose in dietary intervention studies and the magnitude of the effect on diabetes-related risk factors: a systematic review and meta-analysis.
Ruijgrok C, Blaak EE, Egli L, Dussort P, Vinoy S, Rauh SP, Beulens JW, Robertson MD, Alssema M. Ruijgrok C, et al. Eur J Nutr. 2021 Feb;60(1):259-273. doi: 10.1007/s00394-020-02240-1. Epub 2020 Apr 10. Eur J Nutr. 2021. PMID: 32277270 Free PMC article.
Metabolomics and Lipidomics Signatures of Insulin Resistance and Abdominal Fat Depots in People Living with Obesity.
Koay YC, Coster ACF, Chen DL, Milner B, Batarseh A, O'Sullivan JF, Greenfield JR, Samocha-Bonet D. Koay YC, et al. Metabolites. 2022 Dec 15;12(12):1272. doi: 10.3390/metabo12121272. Metabolites. 2022. PMID: 36557310 Free PMC article.

See all "Cited by" articles

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions

LinkOut - more resources

Full Text Sources
- ClinicalKey
- Elsevier Science
Other Literature Sources
- The Lens - Patent Citations Database
- scite Smart Citations
Medical
- MedlinePlus Health Information

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Prevention and Treatment of Type 2 Diabetes: A Pathophysiological-Based Approach

Affiliations

Prevention and Treatment of Type 2 Diabetes: A Pathophysiological-Based Approach

Authors

Affiliations

Abstract

Similar articles

Cited by

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Abstract

Similar articles

Cited by

Publication types

MeSH terms

Substances

Related information

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical