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. 2018 Jan;7(1):25-33.

The Healing Effect of N-Hexan- Dichloromethane Extract Root Onosma Bulbotrichum in Second Degree Burns

Aliasghar Hemmati  1 , Forough Namjuyan  2 , Sadegh Yousefi  3 , Gholamreza Housmand  1 , Hossein Khadem Haghighian  4 , Anahita Rezaei  5
Affiliations

The Healing Effect of N-Hexan- Dichloromethane Extract Root Onosma Bulbotrichum in Second Degree Burns

Aliasghar Hemmati et al. World J Plast Surg. 2018 Jan.

Abstract

Background: Wound healing is the process of repair following an injury to the skin and other soft tissues. In this study, the effect of n-hexane d-chloromethane extract (1: 1) of root Onosma bulbotrichum DC on the second degree burn in rabbit model was investigated.

Methods: Thirty-six adult rabbits of both sexes were randomly divided into six groups, control (without treatment), negative control (treatment with cold cream), positive control (treatment with silver sulfadiazine), and treatment groups with 5%, 1% and 2% O. bulbotrichum cream and assessed histologically.

Results: The best result was shown in 5% O. bulbotrichum group similar to silver sulfadiazine group. The maximum amount of collagen and the tensile strength of tissue were observed in 5% O. bulbotrichum and silver sulfadiazine groups. Histopathological examination showed that burn healing in treatment group with 5% O. bulbotrichum was faster than other groups.

Conclusion: The 5% O. bulbotrichum cream was shown to have healing, and anti-inflammatory effects when used in treatment of second degree burns.

Keywords: Burn; Healing; Onosma bulbotrichum; Rabbit; Silver sulfadiazine.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1
Fig. 1
Comparison of burn healing after treatment with groups of cold cream and without treatment.
Fig. 2
Fig. 2
Comparison of skin wound healing after treatment with silver sulfadiazine and cold cream.
Fig. 3
Fig. 3
Comparison of the rate of healing of skin wounds in groups treated with different concentrations of O. bulbotrichum cream (5%, 2%, and 1%) compared the group treated with cold cream.
Fig. 4
Fig. 4
Comparison of skin wound healing after receiving 5% O. bulbotrichum cream and treatment group with silver sulfadiazine.
Fig. 5
Fig. 5
Comparison of collagen concentrations (µg/section) in all groups.
Fig. 6
Fig. 6
Comparison of non-collagen protein concentrations (µg/section) in all groups.
Fig. 7
Fig. 7
Comparison of histological changes in different groups during the first week: In the group without treatment (A), treatment with cold cream (B), positive silver sulfadiaine control (C) treatment group with 5% O. bulbotrichum cream (D), treatment group with 2% O. bulbotrichum cream (E) treatment group with 1% O. bulbotrichum cream (F).
Fig. 8
Fig. 8
Comparison of histological changes in the second week: In the group without treatment (A), treatment with cold cream (B), positive silver sulfadiazine control (C) treatment group with 5% O. bulbotrichum cream (D), treatment group with cream 2% O. bulbotrichum (E) treatment group with cream 1% O. bulbotrichum (F).
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