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Review
. 2018 Apr 17;57(15):2177-2178.
doi: 10.1021/acs.biochem.8b00013. Epub 2018 Apr 6.

Semisynthetic Organisms with Expanded Genetic Codes

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Review

Semisynthetic Organisms with Expanded Genetic Codes

Yorke Zhang et al. Biochemistry. .

Abstract

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Figures

Figure 1.
Figure 1.
Structure of a natural dA-dT base pair and the dNaM-dTPT3 UBP.
Figure 2.
Figure 2.
The SSO replicates DNA containing the dNaM-dTPT3 UBP (shown in blue and red, respectively), transcribes mRNA and tRNA with complementary codons and anticodons containing NaM or TPT3, uses an orthogonal synthetase to charge the tRNA with an ncAA, and uses them to translate proteins containing ncAAs.

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