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Review
. 2018 Mar 31;19(4):1045.
doi: 10.3390/ijms19041045.

Annexin A1: Uncovering the Many Talents of an Old Protein

Madeeha H Sheikh  1 , Egle Solito  2
Affiliations
Review

Annexin A1: Uncovering the Many Talents of an Old Protein

Madeeha H Sheikh et al. Int J Mol Sci. .

Abstract

Annexin A1 (ANXA1) has long been classed as an anti-inflammatory protein due to its control over leukocyte-mediated immune responses. However, it is now recognized that ANXA1 has widespread effects beyond the immune system with implications in maintaining the homeostatic environment within the entire body due to its ability to affect cellular signalling, hormonal secretion, foetal development, the aging process and development of disease. In this review, we aim to provide a global overview of the role of ANXA1 covering aspects of peripheral and central inflammation, immune repair and endocrine control with focus on the prognostic, diagnostic and therapeutic potential of the molecule in cancer, neurodegeneration and inflammatory-based disorders.

Keywords: ANXA1; CNS; HPA axis; cancer; immune repair; inflammation.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Summary of the role ANXA1 in controlling inflammation through its effect on immune cells.
Figure 2
Figure 2
Summary of the involvement and therapeutic potential of ANXA1 in various disease states within the body.
See this image and copyright information in PMC

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