Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2018 Feb;6(3):54.
doi: 10.21037/atm.2017.11.26.

CMTM6 stabilizes PD-L1 expression and refines its prognostic value in tumors

Emilie Mamessier  1   2 , David J Birnbaum  1   2   3 , Pascal Finetti  1   2 , Daniel Birnbaum  1   2 , François Bertucci  1   2   4
Affiliations
Editorial

CMTM6 stabilizes PD-L1 expression and refines its prognostic value in tumors

Emilie Mamessier et al. Ann Transl Med. 2018 Feb.
No abstract available

PubMed Disclaimer

Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
CMTM6 expression and prognostic value in triple negative breast cancers and in pancreatic ductal adenocarcinoma. (A) Box-plot of mRNA expression levels of CMTM6 and CD274/PD-L1 in our own database of 6,072 primary breast cancers. (B) Kaplan-Meier metastasis-free survival according to CMTM6 mRNA expression in 509 patients with triple negative breast cancer. High and low expressions were defined by reference to the median expression level in the whole breast cancer database including 6,072 samples. The P value if for the log-rank test. (C) Similar to B, but according to both CMTM6 and CD274/PD-L1 mRNA expression. The survival curves of the four groups are color-coded as follows: red for PD-L1high CMTM6high group, green for PD-L1low CMTM6low group, black for PD-L1low CMTM6high group, and blue for PD-L1high CMTM6low group. (D), (E), and (F) Similar to (A), (B), and (C), but in our own database of 695 primary pancreatic ductal adenocarcinomas and for overall survival (n=403).
See this image and copyright information in PMC

Comment on

  • Identification of CMTM6 and CMTM4 as PD-L1 protein regulators.
    Mezzadra R, Sun C, Jae LT, Gomez-Eerland R, de Vries E, Wu W, Logtenberg MEW, Slagter M, Rozeman EA, Hofland I, Broeks A, Horlings HM, Wessels LFA, Blank CU, Xiao Y, Heck AJR, Borst J, Brummelkamp TR, Schumacher TNM. Mezzadra R, et al. Nature. 2017 Sep 7;549(7670):106-110. doi: 10.1038/nature23669. Epub 2017 Aug 16. Nature. 2017. PMID: 28813410 Free PMC article.
  • CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity.
    Burr ML, Sparbier CE, Chan YC, Williamson JC, Woods K, Beavis PA, Lam EYN, Henderson MA, Bell CC, Stolzenburg S, Gilan O, Bloor S, Noori T, Morgens DW, Bassik MC, Neeson PJ, Behren A, Darcy PK, Dawson SJ, Voskoboinik I, Trapani JA, Cebon J, Lehner PJ, Dawson MA. Burr ML, et al. Nature. 2017 Sep 7;549(7670):101-105. doi: 10.1038/nature23643. Epub 2017 Aug 16. Nature. 2017. PMID: 28813417 Free PMC article.

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Ishida Y, Agata Y, Shibahara K, et al. Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. EMBO J 1992;11:3887-95. - PMC - PubMed
    1. Freeman GJ, Long AJ, Iwai Y, et al. Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J Exp Med 2000;192:1027-34. 10.1084/jem.192.7.1027 - DOI - PMC - PubMed
    1. Latchman Y, Wood CR, Chernova T, et al. PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nat Immunol 2001;2:261-8. 10.1038/85330 - DOI - PubMed
    1. Eggermont A, Robert C, Soria JC, et al. Harnessing the immune system to provide long-term survival in patients with melanoma and other solid tumors. Oncoimmunology 2014;3:e27560. 10.4161/onci.27560 - DOI - PMC - PubMed
    1. Sharma P, Allison JP. The future of immune checkpoint therapy. Science 2015;348:56-61. 10.1126/science.aaa8172 - DOI - PubMed