Hepatitis A Virus Genome Organization and Replication Strategy
- PMID: 29610147
- PMCID: PMC6280712
- DOI: 10.1101/cshperspect.a033480
Hepatitis A Virus Genome Organization and Replication Strategy
Abstract
Hepatitis A virus (HAV) is a positive-strand RNA virus classified in the genus Hepatovirus of the family Picornaviridae It is an ancient virus with a long evolutionary history and multiple features of its capsid structure, genome organization, and replication cycle that distinguish it from other mammalian picornaviruses. HAV proteins are produced by cap-independent translation of a single, long open reading frame under direction of an inefficient, upstream internal ribosome entry site (IRES). Genome replication occurs slowly and is noncytopathic, with transcription likely primed by a uridylated protein primer as in other picornaviruses. Newly produced quasi-enveloped virions (eHAV) are released from cells in a nonlytic fashion in a unique process mediated by interactions of capsid proteins with components of the host cell endosomal sorting complexes required for transport (ESCRT) system.
Copyright © 2018 Cold Spring Harbor Laboratory Press; all rights reserved.
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