Epigenetic signatures in cardiac fibrosis, special emphasis on DNA methylation and histone modification

doi:10.1007/s10741-018-9694-z

Review

. 2018 Sep;23(5):789-799.

doi: 10.1007/s10741-018-9694-z.

Epigenetic signatures in cardiac fibrosis, special emphasis on DNA methylation and histone modification

Hui Tao^{1

2}, Zheng-Yu Song¹, Xuan-Sheng Ding³, Jing-Jing Yang⁴, Kai-Hu Shi⁵, Jun Li⁶

Affiliations

¹ School of Basic Medical Sciences and Clinical Pharmacy, China Pharmaceutical University, Nanjing, 210009, Jiangsu Province, China.
² Department of Cardiothoracic Surgery, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, 210028, Jiangsu Province, China.
³ School of Basic Medical Sciences and Clinical Pharmacy, China Pharmaceutical University, Nanjing, 210009, Jiangsu Province, China. dxs0162@sina.com.
⁴ Department of Pharmacology, The Second Hospital of Anhui Medical University, Hefei, 230601, China.
⁵ Department of Cardiothoracic Surgery, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, 210028, Jiangsu Province, China. ayskh163@163.com.
⁶ School of pharmacy, Anhui Medical University, Hefei, 230032, China.

PMID: 29607455
DOI: 10.1007/s10741-018-9694-z

Review

Epigenetic signatures in cardiac fibrosis, special emphasis on DNA methylation and histone modification

Hui Tao et al. Heart Fail Rev. 2018 Sep.

. 2018 Sep;23(5):789-799.

doi: 10.1007/s10741-018-9694-z.

Authors

Hui Tao^{1

2}, Zheng-Yu Song¹, Xuan-Sheng Ding³, Jing-Jing Yang⁴, Kai-Hu Shi⁵, Jun Li⁶

Affiliations

¹ School of Basic Medical Sciences and Clinical Pharmacy, China Pharmaceutical University, Nanjing, 210009, Jiangsu Province, China.
² Department of Cardiothoracic Surgery, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, 210028, Jiangsu Province, China.
³ School of Basic Medical Sciences and Clinical Pharmacy, China Pharmaceutical University, Nanjing, 210009, Jiangsu Province, China. dxs0162@sina.com.
⁴ Department of Pharmacology, The Second Hospital of Anhui Medical University, Hefei, 230601, China.
⁵ Department of Cardiothoracic Surgery, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, 210028, Jiangsu Province, China. ayskh163@163.com.
⁶ School of pharmacy, Anhui Medical University, Hefei, 230032, China.

PMID: 29607455
DOI: 10.1007/s10741-018-9694-z

Abstract

Cardiac fibrosis is defined as excess deposition of extracellular matrix (ECM), resulting in tissue scarring and organ dysfunction. In recent years, despite the underlying mechanisms of cardiac fibrosis are still unknown, numerous studies suggest that epigenetic regulation of cardiac fibrosis. Cardiac fibrosis is regulated by a myriad of factors that converge on the transcription of genes encoding extracellular matrix protein, a process the epigenetic machinery plays a pivotal role. Epigenetic modifications contain three main processes: DNA methylation, histone modifications, and noncoding RNAs. Here, we review recent studies that have illustrated key roles for epigenetic events in the control of pro-fibrotic gene expression, and highlight the potential of molecule mechanisms that target epigenetic regulators as a means of treating cardiac fibrosis.

Keywords: Cardiac fibrosis; DNA methylation; Epigenetic; Histone modification; Noncoding RNA.

PubMed Disclaimer

Cited by

Causal Associations of DNA Methylation and Cardiovascular Disease: A Two-Sample Mendelian Randomization Study.
Gao H, Li J, Ma Q, Zhang Q, Li M, Hu X. Gao H, et al. Glob Heart. 2024 May 14;19(1):48. doi: 10.5334/gh.1324. eCollection 2024. Glob Heart. 2024. PMID: 38765775 Free PMC article.
Epigenetic Regulation in Myocardial Fibroblasts and Its Impact on Cardiovascular Diseases.
Komal S, Gao Y, Wang ZM, Yu QW, Wang P, Zhang LR, Han SN. Komal S, et al. Pharmaceuticals (Basel). 2024 Oct 10;17(10):1353. doi: 10.3390/ph17101353. Pharmaceuticals (Basel). 2024. PMID: 39458994 Free PMC article. Review.
Bidirectional negative feedback actions of DNMT3A and miR-145 in regulating autophagy in cardiac fibroblasts and affecting myocardial fibrosis.
Xu S, Zhang Y, Zhou G, Liu A. Xu S, et al. J Bioenerg Biomembr. 2023 Oct;55(5):341-352. doi: 10.1007/s10863-023-09980-9. Epub 2023 Aug 23. J Bioenerg Biomembr. 2023. PMID: 37610521
Epigenetics and expression of key genes associated with cardiac fibrosis: NLRP3, MMP2, MMP9, CCN2/CTGF and AGT.
Chandra S, Ehrlich KC, Lacey M, Baribault C, Ehrlich M. Chandra S, et al. Epigenomics. 2021 Feb;13(3):219-234. doi: 10.2217/epi-2020-0446. Epub 2021 Feb 4. Epigenomics. 2021. PMID: 33538177 Free PMC article.
Epigenetics in atrial fibrillation: A reappraisal.
Doñate Puertas R, Arora R, Rome S, Asatryan B, Roderick HL, Chevalier P. Doñate Puertas R, et al. Heart Rhythm. 2021 May;18(5):824-832. doi: 10.1016/j.hrthm.2021.01.007. Epub 2021 Jan 10. Heart Rhythm. 2021. PMID: 33440248 Free PMC article. Review.

See all "Cited by" articles

References

1. Nature. 2016 Aug 4;536(7614):100-3 - PubMed
1. Autophagy. 2017 Jun 3;13(6):1004-1024 - PubMed
1. Circulation. 2017 May 30;135(22):2163-2177 - PubMed
1. Curr Med Chem. 2017;24(37):4151-4165 - PubMed
1. Epigenomics. 2016 Jan;8(1):105-17 - PubMed

Publication types

Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions

LinkOut - more resources

Full Text Sources
- Springer
Other Literature Sources
- scite Smart Citations
Medical
- MedlinePlus Health Information

[1] Nature. 2016 Aug 4;536(7614):100-3 - PubMed

[2] Nature. 2016 Aug 4;536(7614):100-3 - PubMed

[3] Autophagy. 2017 Jun 3;13(6):1004-1024 - PubMed

[4] Autophagy. 2017 Jun 3;13(6):1004-1024 - PubMed

[5] Circulation. 2017 May 30;135(22):2163-2177 - PubMed

[6] Circulation. 2017 May 30;135(22):2163-2177 - PubMed

[7] Curr Med Chem. 2017;24(37):4151-4165 - PubMed

[8] Curr Med Chem. 2017;24(37):4151-4165 - PubMed

[9] Epigenomics. 2016 Jan;8(1):105-17 - PubMed

[10] Epigenomics. 2016 Jan;8(1):105-17 - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Epigenetic signatures in cardiac fibrosis, special emphasis on DNA methylation and histone modification

Affiliations

Epigenetic signatures in cardiac fibrosis, special emphasis on DNA methylation and histone modification

Authors

Affiliations

Abstract

Similar articles

Cited by

References

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Abstract

Similar articles

Cited by

References

Publication types

MeSH terms

Substances

Related information

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical