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. 2018 Jul;34(7):1361-1365.
doi: 10.1007/s00381-018-3779-9. Epub 2018 Mar 21.

Predictors of post-discharge seizures in children with traumatic brain injury

Andrew T Hale  1   2 , Kelly Pekala  3   4 , Benjamin Theobald  3   4 , Katherine Kelly  3 , Michael Wolf  5 , John C Wellons  3   6 , Truc Le  5   6 , Chevis N Shannon  3   6
Affiliations

Predictors of post-discharge seizures in children with traumatic brain injury

Andrew T Hale et al. Childs Nerv Syst. 2018 Jul.

Abstract

Purpose: In traumatic brain injury (TBI), hyperglycemia and hypothermia are thought to be associated with poor outcomes, but have not been systematically studied in children. Thus, our aim was to evaluate whether serum glucose and temperature at admission, among other clinical variables, were associated with need for post hospital-discharge seizure medication in children diagnosed with TBI.

Methods: We performed a retrospective study of 1814 children who were diagnosed with TBI at a tertiary pediatric hospital. Serum glucose levels at admission and temperature at initial presentation, 12, and 24 h were collected. Ongoing seizure activity was defined as discharge prescription of a seizure-modifying medication.

Results: We identified 121 patients with need for continued seizure medications, and 80 patients expired. Independent predictors of prolonged seizures included serum glucose levels above 140 mg/dl (p < 0.003) and 199 mg/dl (p < 0.001), hypothermia (<35 °C), subdural hematoma (p < 0.001), midline shift (p < 0.001), and > 1% temperature change in the first 24 h (p < 0.001). Multivariate regression adjusting for GCS revealed that bilateral bleed (p = 0.008), body-temperature instability (p = 0.026), subdural hematoma (p < 0.001), and mechanism of injury (p = 0.007) were predictive of prolonged seizure activity.

Conclusions: In summary, we conclude that body temperature may be playing a more significant role than glycemic control in propensity for ongoing seizure activity in children sustaining TBI.

Keywords: Pediatric; Seizure; Traumatic brain injury.

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