Meta-analysis of the prognostic value of long non-coding RNA AFAP1-AS1 for cancer patients in China
- PMID: 29487718
- PMCID: PMC5814285
- DOI: 10.18632/oncotarget.23568
Meta-analysis of the prognostic value of long non-coding RNA AFAP1-AS1 for cancer patients in China
Abstract
LncRNA actin filament-associated protein 1 antisense RNA 1 (AFAP1-AS1) is often dysregulated in cancer. We performed this meta-analysis to clarify the usefulness of AFAP1-AS1 as a prognostic marker in malignant tumors. The PubMed, Medline, OVID, Cochrane Library, and Web of Science databases were searched from inception to Augest 7, 2017. Sixteen studies with a total of 1,386 patients were included in the study. The pooled hazard ratio (HR) suggested high AFAP1-AS1 expression correlated with poor overall survival (OS) (HR = 1.98, 95% confidence interval (CI): 1.71-2.28), disease-free survival (DFS) (HR = 1.54, 95% CI: 1.22-1.95), and progression-free survival (PFS) (HR = 2.17, 95% CI:1.64-2.88) in cancer patients, without obvious heterogeneity. High AFAP1-AS1 expression also correlated with larger tumor size (odds ratio (OR) = 2.04, 95% CI: 1.54-2.72), advanced tumor stage (OR=2.35, 95% CI: 1.70-3.26), poor histological grade (OR =1.39, 95% CI: 1.02-1.90), lymph node metastasis (OR = 2.71, 95% CI: 1.98-3.72) and distant metastasis (OR = 2.96, 95% CI: 2.03-4.32). Thus high AFAP1-AS1 expression is predictive of poor OS, DFS, PFS, lymph node metastasis, distant metastasis, histological grade, larger tumor size and tumor stage, which suggests high AFAP1-AS1 expression may serve as a novel biomarker of poor prognosis in cancer.
Keywords: AFAP1-AS1; LncRNA; metastasis; neoplasms; prognosis.
Conflict of interest statement
CONFLICTS OF INTEREST The authors declare that there is no conflicts of interests regarding the publication of this paper.
Figures
Similar articles
-
The role of long non-coding RNA AFAP1-AS1 in human malignant tumors.Pathol Res Pract. 2018 Oct;214(10):1524-1531. doi: 10.1016/j.prp.2018.08.014. Epub 2018 Aug 20. Pathol Res Pract. 2018. PMID: 30173945 Review.
-
The prognostic value of high LncRNA AFAP1-AS1 expression in various cancers: A systematic review and meta-analysis containing 21 studies.Clin Chim Acta. 2018 Jun;481:147-153. doi: 10.1016/j.cca.2018.03.006. Epub 2018 Mar 12. Clin Chim Acta. 2018. PMID: 29544748 Review.
-
Prognostic and clinical significance of long non-coding RNA HNF1A-AS1 in solid cancers: A systematic review and meta-analysis.Medicine (Baltimore). 2019 Dec;98(49):e18264. doi: 10.1097/MD.0000000000018264. Medicine (Baltimore). 2019. PMID: 31804362 Free PMC article.
-
Long noncoding RNA AFAP1-AS1, a potential novel biomarker to predict the clinical outcome of cancer patients: a meta-analysis.Onco Targets Ther. 2016 Jul 12;9:4247-54. doi: 10.2147/OTT.S107188. eCollection 2016. Onco Targets Ther. 2016. PMID: 27471399 Free PMC article.
-
Circulating long non-coding RNA AFAP1-AS1 is a potential diagnostic biomarker for non-small cell lung cancer.Clin Chim Acta. 2017 Dec;475:152-156. doi: 10.1016/j.cca.2017.10.027. Epub 2017 Nov 6. Clin Chim Acta. 2017. PMID: 29080690
Cited by
-
Long Non-Coding RNAs as Potential Diagnostic and Prognostic Biomarkers in Breast Cancer: Progress and Prospects.Front Oncol. 2021 Aug 30;11:710538. doi: 10.3389/fonc.2021.710538. eCollection 2021. Front Oncol. 2021. PMID: 34527584 Free PMC article. Review.
-
Formononetin relieves the facilitating effect of lncRNA AFAP1-AS1-miR-195/miR-545 axis on progression and chemo-resistance of triple-negative breast cancer.Aging (Albany NY). 2021 Jul 21;13(14):18191-18222. doi: 10.18632/aging.203156. Epub 2021 Jul 21. Aging (Albany NY). 2021. PMID: 34289449 Free PMC article.
-
AFAP1-AS1: a rising star among oncogenic long non-coding RNAs.Sci China Life Sci. 2021 Oct;64(10):1602-1611. doi: 10.1007/s11427-020-1874-6. Epub 2021 May 13. Sci China Life Sci. 2021. PMID: 33999309 Review.
-
AFAP1 and its naturally occurring antisense RNA are downregulated in gastric cancer samples.Biomed Rep. 2019 May;10(5):296-302. doi: 10.3892/br.2019.1207. Epub 2019 Apr 15. Biomed Rep. 2019. PMID: 31086663 Free PMC article.
References
-
- Siegel RL, Miller KD, Jemal A. Cancer Statistics, 2017. CA Cancer J Clin. 2017;67:7–30. - PubMed
-
- Fan YH, Fang H, Ji CX, Xie H, Xiao B, Zhu XG. Long noncoding RNA CCAT2 can predict metastasis and poor prognosis: A meta-analysis. Clin Chim Acta. 2017;466:120–126. - PubMed
-
- Liu T, Zhang X, Gao S, Jing F, Yang Y, Du L, Zheng G, Li P, Li C, Wang C. Exosomal long noncoding RNA CRNDE-h as a novel serum-based biomarker for diagnosis and prognosis of colorectal cancer. Oncotarget. 2016;7:85551–85563. http://doi.org/10.18632/oncotarget.13465 - DOI - PMC - PubMed
-
- Cheng N, Li X, Zhao C, Ren S, Chen X, Cai W, Zhao M, Zhang Y, Li J, Wang Q, Zhou C. Microarray expression profile of long non-coding RNAs in EGFR-TKIs resistance of human non-small cell lung cancer. Oncol Rep. 2015;33:833–839. - PubMed
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials