Lipid Droplets as Immune Modulators in Myeloid Cells

doi:10.1016/j.it.2018.01.012

Review

. 2018 May;39(5):380-392.

doi: 10.1016/j.it.2018.01.012. Epub 2018 Feb 22.

Lipid Droplets as Immune Modulators in Myeloid Cells

Martijn H den Brok¹, Tonke K Raaijmakers¹, Estel Collado-Camps², Gosse J Adema³

Affiliations

¹ Department of Radiation Oncology, Radiotherapy & OncoImmunology Laboratory, Radboud Institute for Molecular Life Sciences, Radboud UMC, Geert Grooteplein Zuid 32, 6525 GA, Nijmegen, The Netherlands; Department of Anesthesiology, Pain and Palliative Medicine, Radboud UMC, Geert Grooteplein 10, 6525 GA Nijmegen, The Netherlands.
² Department of Radiation Oncology, Radiotherapy & OncoImmunology Laboratory, Radboud Institute for Molecular Life Sciences, Radboud UMC, Geert Grooteplein Zuid 32, 6525 GA, Nijmegen, The Netherlands.
³ Department of Radiation Oncology, Radiotherapy & OncoImmunology Laboratory, Radboud Institute for Molecular Life Sciences, Radboud UMC, Geert Grooteplein Zuid 32, 6525 GA, Nijmegen, The Netherlands. Electronic address: Gosse.Adema@radboudumc.nl.

PMID: 29478771
DOI: 10.1016/j.it.2018.01.012

Review

Lipid Droplets as Immune Modulators in Myeloid Cells

Martijn H den Brok et al. Trends Immunol. 2018 May.

. 2018 May;39(5):380-392.

doi: 10.1016/j.it.2018.01.012. Epub 2018 Feb 22.

Authors

Martijn H den Brok¹, Tonke K Raaijmakers¹, Estel Collado-Camps², Gosse J Adema³

Affiliations

¹ Department of Radiation Oncology, Radiotherapy & OncoImmunology Laboratory, Radboud Institute for Molecular Life Sciences, Radboud UMC, Geert Grooteplein Zuid 32, 6525 GA, Nijmegen, The Netherlands; Department of Anesthesiology, Pain and Palliative Medicine, Radboud UMC, Geert Grooteplein 10, 6525 GA Nijmegen, The Netherlands.
² Department of Radiation Oncology, Radiotherapy & OncoImmunology Laboratory, Radboud Institute for Molecular Life Sciences, Radboud UMC, Geert Grooteplein Zuid 32, 6525 GA, Nijmegen, The Netherlands.
³ Department of Radiation Oncology, Radiotherapy & OncoImmunology Laboratory, Radboud Institute for Molecular Life Sciences, Radboud UMC, Geert Grooteplein Zuid 32, 6525 GA, Nijmegen, The Netherlands. Electronic address: Gosse.Adema@radboudumc.nl.

PMID: 29478771
DOI: 10.1016/j.it.2018.01.012

Abstract

Lipid droplets (LDs) were initially described as fat storage organelles in adipocytes, but are increasingly recognized as dynamic players in lipid metabolism, with important roles not only in diseases such as diabetes and cancer, but also in immune regulation. Alterations in immune cell function, such as myeloid cell activation, are connected to profound changes in LD numbers and LD protein composition. Thus, these organelles appear to be essential to metabolically support immune responses, and have a vital role in antigen crosspresentation, interferon (IFN) responses, production of inflammatory mediators, and pathogen clearance. Here, we review recent studies that report on the role of LDs in the modulation of immune cell function, primarily focusing on myeloid cells, such as macrophages and dendritic cells (DCs).

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Lipid Droplets as Immune Modulators in Myeloid Cells

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Lipid Droplets as Immune Modulators in Myeloid Cells

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