Recent advances in hyaluronic acid based therapy for osteoarthritis

doi:10.1186/s40169-017-0180-3

Review

. 2018 Feb 16;7(1):6.

doi: 10.1186/s40169-017-0180-3.

Recent advances in hyaluronic acid based therapy for osteoarthritis

Steven Bowman¹, Mohamed E Awad², Mark W Hamrick^{3

4}, Monte Hunter¹, Sadanand Fulzele^{5

6}

Affiliations

¹ Department of Orthopedics, Augusta University, 30904, Augusta, Georgia.
² Department of Oral Biology, Augusta University, Augusta, Georgia.
³ Department of Cell Biology and Anatomy, Augusta University, Augusta, Georgia.
⁴ Institute of Regenerative and Reparative Medicine, Augusta University, Augusta, Georgia.
⁵ Department of Orthopedics, Augusta University, 30904, Augusta, Georgia. sfulzele@augusta.edu.
⁶ Institute of Regenerative and Reparative Medicine, Augusta University, Augusta, Georgia. sfulzele@augusta.edu.

PMID: 29450666
PMCID: PMC5814393
DOI: 10.1186/s40169-017-0180-3

Review

Recent advances in hyaluronic acid based therapy for osteoarthritis

Steven Bowman et al. Clin Transl Med. 2018.

. 2018 Feb 16;7(1):6.

doi: 10.1186/s40169-017-0180-3.

Authors

Steven Bowman¹, Mohamed E Awad², Mark W Hamrick^{3

4}, Monte Hunter¹, Sadanand Fulzele^{5

6}

Affiliations

¹ Department of Orthopedics, Augusta University, 30904, Augusta, Georgia.
² Department of Oral Biology, Augusta University, Augusta, Georgia.
³ Department of Cell Biology and Anatomy, Augusta University, Augusta, Georgia.
⁴ Institute of Regenerative and Reparative Medicine, Augusta University, Augusta, Georgia.
⁵ Department of Orthopedics, Augusta University, 30904, Augusta, Georgia. sfulzele@augusta.edu.
⁶ Institute of Regenerative and Reparative Medicine, Augusta University, Augusta, Georgia. sfulzele@augusta.edu.

PMID: 29450666
PMCID: PMC5814393
DOI: 10.1186/s40169-017-0180-3

Abstract

Osteoarthritis is a debilitating disease that has increased in prevalence across the world due to the aging population. Currently, physicians use a plethora of treatment strategies to try and slow down the progression of the disease, but none have been shown to ubiquitously treat and cure the disease. One of the strategies uses the high molecular weight molecule hyaluronic acid as either an injectable or oral supplement for treatment. Hyaluronic acid (HA) is a relatively new treatment that has shown varied results through several clinical trials. It can be used as a scaffold for engineering new treatments and several new preparations have just been added to the market. A comprehensive search was conducted through several search databases according our inclusion and exclusion criteria. This review included 44 prospective clinical trial investigating the feasibility and efficacy of HA injection for knee, hip, and ankle osteoarthritis. This review will take a closer look at hyaluronic acid and its properties, as well clinical effectiveness and future options.

Keywords: Hyaluronic acid (HA); Osteoarthritis; Tissue engineering; Treatment.

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Figures

**Fig. 1**
Flow chart showing study identification, inclusion, and exclusion

See this image and copyright information in PMC

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References

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[1] Berenbaum F. Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!) Osteoarthr Cartil. 2013;21(1):16–21. doi: 10.1016/j.joca.2012.11.012. - DOI - PubMed

[2] Berenbaum F. Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!) Osteoarthr Cartil. 2013;21(1):16–21. doi: 10.1016/j.joca.2012.11.012. - DOI - PubMed

[3] CDC Prevalence of doctor-diagnosed arthritis and arthritis-attributable activity limitation—United States, 2010–2012. MMWR. 2013;62:869–873. - PMC - PubMed

[4] CDC Prevalence of doctor-diagnosed arthritis and arthritis-attributable activity limitation—United States, 2010–2012. MMWR. 2013;62:869–873. - PMC - PubMed

[5] Barbour K, et al. Meeting physical activity guidelines and the risk of incident knee osteoarthritis: the Johnston County Osteoarthritis Project. Arthritis Care Res (Hoboken) 2014;66(1):139–146. doi: 10.1002/acr.22120. - DOI - PMC - PubMed

[6] Barbour K, et al. Meeting physical activity guidelines and the risk of incident knee osteoarthritis: the Johnston County Osteoarthritis Project. Arthritis Care Res (Hoboken) 2014;66(1):139–146. doi: 10.1002/acr.22120. - DOI - PMC - PubMed

[7] Moskowitz RW. The burden of osteoarthritis: clinical and quality-of-life issues. Am J Manag Care. 2009;15(8 Suppl):S223–S229. - PubMed

[8] Moskowitz RW. The burden of osteoarthritis: clinical and quality-of-life issues. Am J Manag Care. 2009;15(8 Suppl):S223–S229. - PubMed

[9] Puig-Junoy J, Ruiz Zamora A. Socio-economic costs of osteoarthritis: a systematic review of cost-of-illness studies. Semin Arthritis Rheum. 2015;44(5):531–541. doi: 10.1016/j.semarthrit.2014.10.012. - DOI - PubMed

[10] Puig-Junoy J, Ruiz Zamora A. Socio-economic costs of osteoarthritis: a systematic review of cost-of-illness studies. Semin Arthritis Rheum. 2015;44(5):531–541. doi: 10.1016/j.semarthrit.2014.10.012. - DOI - PubMed

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Recent advances in hyaluronic acid based therapy for osteoarthritis

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Recent advances in hyaluronic acid based therapy for osteoarthritis

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