Nanomedicine: An effective tool in cancer therapy

doi:10.1016/j.ijpharm.2018.02.007

Review

. 2018 Apr 5;540(1-2):132-149.

doi: 10.1016/j.ijpharm.2018.02.007. Epub 2018 Feb 7.

Nanomedicine: An effective tool in cancer therapy

Saima Aftab¹, Afzal Shah², Akhtar Nadhman¹, Sevinc Kurbanoglu³, Sibel Aysıl Ozkan³, Dionysios D Dionysiou⁴, Shyam S Shukla⁵, Tejraj M Aminabhavi⁶

Affiliations

¹ Department of Chemistry, Quaid-i-Azam University, 45320 Islamabad, Pakistan.
² Department of Chemistry, Quaid-i-Azam University, 45320 Islamabad, Pakistan; Ankara University, Faculty of Pharmacy, Department of Analytical Chemistry, Tandogan, 06100 Ankara, Turkey. Electronic address: afzals_qau@yahoo.com.
³ Ankara University, Faculty of Pharmacy, Department of Analytical Chemistry, Tandogan, 06100 Ankara, Turkey.
⁴ Environmental Engineering and Science Program, Department of Biomedical, Chemical and Environmental Engineering, University of Cincinnati, Cincinnati, OH 45221-0012, USA.
⁵ Department of Chemistry and Biochemistry, Lamar University, Beaumont, TX 77710, USA.
⁶ Department of Chemistry and Biochemistry, Lamar University, Beaumont, TX 77710, USA. Electronic address: aminabhavit@gmail.com.

PMID: 29427746
DOI: 10.1016/j.ijpharm.2018.02.007

Review

Nanomedicine: An effective tool in cancer therapy

Saima Aftab et al. Int J Pharm. 2018.

. 2018 Apr 5;540(1-2):132-149.

doi: 10.1016/j.ijpharm.2018.02.007. Epub 2018 Feb 7.

Authors

Saima Aftab¹, Afzal Shah², Akhtar Nadhman¹, Sevinc Kurbanoglu³, Sibel Aysıl Ozkan³, Dionysios D Dionysiou⁴, Shyam S Shukla⁵, Tejraj M Aminabhavi⁶

Affiliations

¹ Department of Chemistry, Quaid-i-Azam University, 45320 Islamabad, Pakistan.
² Department of Chemistry, Quaid-i-Azam University, 45320 Islamabad, Pakistan; Ankara University, Faculty of Pharmacy, Department of Analytical Chemistry, Tandogan, 06100 Ankara, Turkey. Electronic address: afzals_qau@yahoo.com.
³ Ankara University, Faculty of Pharmacy, Department of Analytical Chemistry, Tandogan, 06100 Ankara, Turkey.
⁴ Environmental Engineering and Science Program, Department of Biomedical, Chemical and Environmental Engineering, University of Cincinnati, Cincinnati, OH 45221-0012, USA.
⁵ Department of Chemistry and Biochemistry, Lamar University, Beaumont, TX 77710, USA.
⁶ Department of Chemistry and Biochemistry, Lamar University, Beaumont, TX 77710, USA. Electronic address: aminabhavit@gmail.com.

PMID: 29427746
DOI: 10.1016/j.ijpharm.2018.02.007

Abstract

Various types of nanoparticles (NPs) have been used in delivering anticancer drugs to the site of action. This area has become more attractive in recent years due to optimal size and negligible undesirable side effects caused by the NPs. The focus of this review is to explore various types of NPs and their surface/chemical modifications as well as attachment of targeting ligands for tuning their properties in order to facilitate targeted delivery to the cancer sites in a rate-controlled manner. Heme compatibility, biodistribution, longer circulation time, hydrophilic lipophilic balance for high bioavailability, prevention of drug degradation and leakage are important in transporting drugs to the targeted cancer sites. The review discusses advantages of polymeric, magnetic, gold, and mesoporous silica NPs in delivering chemotherapeutic agents over the conventional dosage formulations along with their shortcomings/risks and possible solutions/alternatives.

Keywords: Blood brain barrier; Cancer therapy; Controlled release; Nanomedicine; Targeted drug delivery.

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Nanomedicine: An effective tool in cancer therapy

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Nanomedicine: An effective tool in cancer therapy

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