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Review
. 2018 Aug;66(4):245-266.
doi: 10.1007/s00005-018-0506-x. Epub 2018 Feb 7.

Humanized Mice as Unique Tools for Human-Specific Studies

Kylie Su Mei Yong  1   2 , Zhisheng Her  1 , Qingfeng Chen  3   4   5
Affiliations
Review

Humanized Mice as Unique Tools for Human-Specific Studies

Kylie Su Mei Yong et al. Arch Immunol Ther Exp (Warsz). 2018 Aug.

Abstract

With an increasing human population, medical research is pushed to progress into an era of precision therapy. Humanized mice are at the very heart of this new forefront where it is acutely required to decipher human-specific disease pathogenesis and test an array of novel therapeutics. In this review, "humanized" mice are defined as immunodeficient mouse engrafted with functional human biological systems. Over the past decade, researchers have been conscientiously making improvements on the development of humanized mice as a model to closely recapitulate disease pathogenesis and drug mechanisms in humans. Currently, literature is rife with descriptions of novel and innovative humanized mouse models that hold a significant promise to become a panacea for drug innovations to treat and control conditions such as infectious disease and cancer. This review will focus on the background of humanized mice, diseases, and human-specific therapeutics tested on this platform as well as solutions to improve humanized mice for future clinical use.

Keywords: Drug testing; Human diseases; Human specificity; Humanized mice; Precision therapy.

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References

    1. Akkina R. New generation humanized mice for virus research: comparative aspects and future prospects. Virology. 2013;435:14–28. - PMC - PubMed
    1. Ali N, Flutter B, Sanchez Rodriguez R, et al. Xenogeneic graft-versus-host-disease in NOD-scid IL-2Rγnull mice display a T-effector memory phenotype. PLoS One. 2012;7:e44219. - PMC - PubMed
    1. Amaladoss A, Chen Q, Liu M, et al. De novo generated human red blood cells in humanized mice support Plasmodium falciparum infection. PLoS One. 2015;10:e0129825. - PMC - PubMed
    1. Ames E, Canter RJ, Grossenbacher SK, et al. NK cells preferentially target tumor cells with a cancer stem cell phenotype. J Immunol. 2015;195:4010–4019. - PMC - PubMed
    1. Andrade D, Redecha PB, Vukelic M, et al. Engraftment of PBMC from SLE and APS donors into BALB-Rag2/IL2Rgc/ mice: a promising model for studying human disease. Arthritis Rheum. 2011;63:2764–2773. - PMC - PubMed