Chemokines in homeostasis and diseases

doi:10.1038/cmi.2017.134

Review

. 2018 Apr;15(4):324-334.

doi: 10.1038/cmi.2017.134. Epub 2018 Jan 29.

Chemokines in homeostasis and diseases

Keqiang Chen¹, Zhiyao Bao^{1

2}, Peng Tang^{1

3}, Wanghua Gong⁴, Teizo Yoshimura⁵, Ji Ming Wang⁶

Affiliations

¹ Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute at Frederick, 21702, Frederick, MD, USA.
² Department of Pulmonary & Critical Care Medicine, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 200025, Shanghai, P. R. China.
³ Department of Breast Surgery, Southwest Hospital, Third Military Medical University, 400038, Chongqing, China.
⁴ Basic Research Program, Leidos Biomedical Research, Inc., 21702, Frederick, MD, USA.
⁵ Department of Pathology and Experimental Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 700-8558, Okayama, Japan.
⁶ Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute at Frederick, 21702, Frederick, MD, USA. wangji@mail.nih.gov.

PMID: 29375126
PMCID: PMC6052829
DOI: 10.1038/cmi.2017.134

Review

Chemokines in homeostasis and diseases

Keqiang Chen et al. Cell Mol Immunol. 2018 Apr.

. 2018 Apr;15(4):324-334.

doi: 10.1038/cmi.2017.134. Epub 2018 Jan 29.

Authors

Keqiang Chen¹, Zhiyao Bao^{1

2}, Peng Tang^{1

3}, Wanghua Gong⁴, Teizo Yoshimura⁵, Ji Ming Wang⁶

Affiliations

¹ Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute at Frederick, 21702, Frederick, MD, USA.
² Department of Pulmonary & Critical Care Medicine, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 200025, Shanghai, P. R. China.
³ Department of Breast Surgery, Southwest Hospital, Third Military Medical University, 400038, Chongqing, China.
⁴ Basic Research Program, Leidos Biomedical Research, Inc., 21702, Frederick, MD, USA.
⁵ Department of Pathology and Experimental Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 700-8558, Okayama, Japan.
⁶ Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute at Frederick, 21702, Frederick, MD, USA. wangji@mail.nih.gov.

PMID: 29375126
PMCID: PMC6052829
DOI: 10.1038/cmi.2017.134

Abstract

For the past twenty years, chemokines have emerged as a family of critical mediators of cell migration during immune surveillance, development, inflammation and cancer progression. Chemokines bind to seven transmembrane G protein-coupled receptors (GPCRs) that are expressed by a wide variety of cell types and cause conformational changes in trimeric G proteins that trigger the intracellular signaling pathways necessary for cell movement and activation. Although chemokines have evolved to benefit the host, inappropriate regulation or utilization of these small proteins may contribute to or even cause diseases. Therefore, understanding the role of chemokines and their GPCRs in the complex physiological and diseased microenvironment is important for the identification of novel therapeutic targets. This review introduces the functional array and signals of multiple chemokine GPCRs in guiding leukocyte trafficking as well as their roles in homeostasis, inflammation, immune responses and cancer.

Keywords: GPCRs; chemokines; chemotaxis; diseases; homeostasis; inflammatory cells.

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Conflict of interest statement

The authors declare no conflict of interest.

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References

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1. Chen K, Liu M, Liu Y, Wang C, Yoshimura T, Gong W, et al. Signal relay by CC chemokine receptor 2 (CCR2) and formylpeptide receptor 2 (Fpr2) in the recruitment of monocyte-derived dendritic cells in allergic airway inflammation. J Biol Chem. 2013;288:16262–16273. - PMC - PubMed
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[1] Le Y, Zhou Y, Iribarren P, Wang J. Chemokines and chemokine receptors: their manifold roles in homeostasis and disease. Cell Mol Immunol. 2004;1:95–104. - PubMed

[2] Le Y, Zhou Y, Iribarren P, Wang J. Chemokines and chemokine receptors: their manifold roles in homeostasis and disease. Cell Mol Immunol. 2004;1:95–104. - PubMed

[3] Chen K, Liu M, Liu Y, Wang C, Yoshimura T, Gong W, et al. Signal relay by CC chemokine receptor 2 (CCR2) and formylpeptide receptor 2 (Fpr2) in the recruitment of monocyte-derived dendritic cells in allergic airway inflammation. J Biol Chem. 2013;288:16262–16273. - PMC - PubMed

[4] Chen K, Liu M, Liu Y, Wang C, Yoshimura T, Gong W, et al. Signal relay by CC chemokine receptor 2 (CCR2) and formylpeptide receptor 2 (Fpr2) in the recruitment of monocyte-derived dendritic cells in allergic airway inflammation. J Biol Chem. 2013;288:16262–16273. - PMC - PubMed

[5] Nagarsheth N, Wicha MS, Zou W. Chemokines in the cancer microenvironment and their relevance in cancer immunotherapy. Nat Rev Immunol. 2017;17:559–572. - PMC - PubMed

[6] Nagarsheth N, Wicha MS, Zou W. Chemokines in the cancer microenvironment and their relevance in cancer immunotherapy. Nat Rev Immunol. 2017;17:559–572. - PMC - PubMed

[7] Griffith JW, Sokol CL, Luster AD. Chemokines and chemokine receptors: positioning cells for host defense and immunity. Annu Rev Immunol. 2014;32:659–702. - PubMed

[8] Griffith JW, Sokol CL, Luster AD. Chemokines and chemokine receptors: positioning cells for host defense and immunity. Annu Rev Immunol. 2014;32:659–702. - PubMed

[9] Schulz O, Hammerschmidt SI, Moschovakis GL, Forster R. Chemokines and chemokine receptors in lymphoid tissue dynamics. Annu Rev Immunol. 2016;34:203–242. - PubMed

[10] Schulz O, Hammerschmidt SI, Moschovakis GL, Forster R. Chemokines and chemokine receptors in lymphoid tissue dynamics. Annu Rev Immunol. 2016;34:203–242. - PubMed

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Chemokines in homeostasis and diseases

Affiliations

Chemokines in homeostasis and diseases

Authors

Affiliations

Abstract

Conflict of interest statement

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Grants and funding

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