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. 2017 Oct 20;8(68):113202-113212.
doi: 10.18632/oncotarget.21912. eCollection 2017 Dec 22.

Curative versus palliative treatments for colorectal cancer with peritoneal carcinomatosis: a systematic review and meta-analysis

Wenqiong Wu  1 , Shipeng Yan  2 , Xianzhen Liao  2 , Haifang Xiao  2 , Zhongxi Fu  3 , Lizhang Chen  4 , Jinsong Mou  5 , Haibo Yu  6 , Lian Zhao  7   8 , Xiangguo Liu  2
Affiliations

Curative versus palliative treatments for colorectal cancer with peritoneal carcinomatosis: a systematic review and meta-analysis

Wenqiong Wu et al. Oncotarget. .

Abstract

The objective of this study was to provide an up-to-date summary of the current evidence that may be useful for updating guidelines. We comprehensively searched the published literatures and conferences for studies that compared curative with palliative treatments in colorectal cancer patients with peritoneal metastasis. The primary outcomes considered in this study were three- and five-year overall survival rates. We pooled data across studies and estimated summary effect sizes. Overall, patients who received curative treatments had improved three-year survival (hazard ratio (HR), 2.19 [95% CI, 1.83 to 2.62]) and five-year survival (HR, 2.22 [95% CI, 1.83 to 2.69]) compared with those who received palliative treatments. Patients who received curative treatments had an increased risk of treatment-related morbidity (odds ratio (OR), 2.90 [95% CI, 2.02 to 4.17]), but there was no significant difference in treatment-related mortality between patients who received curative treatments and those who received palliative treatments (OR, 1.46 [CI, 0.62 to 3.47]). Curative treatments improved overall survival in colorectal cancer patients with peritoneal metastasis and did not increase the risk of treatment-related mortality. Curative treatments were associated with a higher risk of treatment-related morbidity. These data highlight the importance for further investigation aimed at prevention of treatment-associated morbidity.

Keywords: colorectal cancer; cytoreductive surgery; intraperitoneal chemotherapy; meta-analysis; peritoneal carcinomatosis.

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Conflict of interest statement

CONFLICTS OF INTEREST The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1. Summary of evidence search and selection
Figure 2
Figure 2. Risk of bias assessment of included RCTs
Figure 3
Figure 3. Overall survival comparing curative versus palliative treatments, stratified by three- and five-year survival
Figure 4
Figure 4. Overall treatment-associated morbidity and mortality comparing curative versus palliative treatments
See this image and copyright information in PMC

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