Impaired intracellular transport of class I MHC antigens as a possible means for adenoviruses to evade immune surveillance
- PMID: 2934137
- DOI: 10.1016/0092-8674(85)90026-1
Impaired intracellular transport of class I MHC antigens as a possible means for adenoviruses to evade immune surveillance
Abstract
Early region E3 of adenovirus-2 encodes a glycoprotein, E19, that associates with class I MHC antigens. The interaction occurs concomitantly with abrogated terminal glycosylation of class I antigen heavy chains, as shown by pulse-chase and Endo H digestion experiments. Also the viral protein remains in the high mannose form throughout the chase period. These results do not reflect a general impairment of terminal glycosylation of membrane proteins. Immunofluorescence analyses demonstrated that in virally infected cells E19 and class I antigens accumulate in the perinuclear region. Class I antigens gradually disappear from the cell surface. A diminished cell surface expression of class I antigens may be a means by which adenoviruses evade immune surveillance.
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