A PINK1-mediated mitophagy pathway decides the fate of tumors-to be benign or malignant?

doi:10.1080/15548627.2018.1425057

. 2018;14(4):563-566.

doi: 10.1080/15548627.2018.1425057. Epub 2018 Feb 21.

A PINK1-mediated mitophagy pathway decides the fate of tumors-to be benign or malignant?

Hui Qian¹, Xiaojuan Chao¹, Wen-Xing Ding¹

Affiliations

PMID: 29313453
PMCID: PMC5959334
DOI: 10.1080/15548627.2018.1425057

A PINK1-mediated mitophagy pathway decides the fate of tumors-to be benign or malignant?

Hui Qian et al. Autophagy. 2018.

. 2018;14(4):563-566.

doi: 10.1080/15548627.2018.1425057. Epub 2018 Feb 21.

Authors

Hui Qian¹, Xiaojuan Chao¹, Wen-Xing Ding¹

Affiliation

¹ a Department of Pharmacology, Toxicology and Therapeutics , University of Kansas Medical Center , Kansas City , KS , USA.

PMID: 29313453
PMCID: PMC5959334
DOI: 10.1080/15548627.2018.1425057

Abstract

Macroautophagy/autophagy plays a dual role in cancer depending on the stage of tumorigenesis. Autophagy prevents tumor initiation by suppressing chronic tissue damage, inflammation, accumulation of damaged organelles and genome instability. Autophagy can also sustain tumor metabolism and provide nutrients for tumor growth and survival via nutrient recycling. Moreover, autophagy is required for benign tumors to progress to malignant tumors. Emerging evidence indicates that autophagy or mitophagy can inactivate tumor suppressors such as TP53/TRP53/p53 to promote tumor progression once carcinogenesis has been initiated.

Keywords: Autophagy; hepatocellular carcinoma; mitophagy; p53; tumorigenesis.

PubMed Disclaimer

Cited by

Hibiscus manihot L. flower extract induces anticancer activity through modulation of apoptosis and autophagy in A549 cells.
Xu M, Zhao M, Zhu M, Yuan H, Li Z, Yan P, Ma C, Zhao H, Wang S, Wan R, Wang L, Yu G. Xu M, et al. Sci Rep. 2024 Apr 6;14(1):8102. doi: 10.1038/s41598-024-58439-3. Sci Rep. 2024. PMID: 38582921 Free PMC article.
Zinc oxide nanoparticles induce toxicity in CAL 27 oral cancer cell lines by activating PINK1/Parkin-mediated mitophagy.
Wang J, Gao S, Wang S, Xu Z, Wei L. Wang J, et al. Int J Nanomedicine. 2018 Jun 20;13:3441-3450. doi: 10.2147/IJN.S165699. eCollection 2018. Int J Nanomedicine. 2018. PMID: 29950828 Free PMC article.
Mitoepigenetics pathways and natural compounds: a dual approach to combatting hepatocellular carcinoma.
Hatawsh A, Al-Haddad RH, Okafor UG, Diab LM, Dekanoidze N, Abdulwahab AA, Mohammed OA, Doghish AS, Moussa R, Elimam H. Hatawsh A, et al. Med Oncol. 2024 Oct 27;41(12):302. doi: 10.1007/s12032-024-02538-8. Med Oncol. 2024. PMID: 39465473 Review.
Flubendazole induces mitochondrial dysfunction and DRP1-mediated mitophagy by targeting EVA1A in breast cancer.
Zhen Y, Yuan Z, Zhang J, Chen Y, Fu Y, Liu Y, Fu L, Zhang L, Zhou XL. Zhen Y, et al. Cell Death Dis. 2022 Apr 19;13(4):375. doi: 10.1038/s41419-022-04823-8. Cell Death Dis. 2022. PMID: 35440104 Free PMC article.
Unraveling the Janus-Faced Role of Autophagy in Hepatocellular Carcinoma: Implications for Therapeutic Interventions.
Nguyen TH, Nguyen TM, Ngoc DTM, You T, Park MK, Lee CH. Nguyen TH, et al. Int J Mol Sci. 2023 Nov 13;24(22):16255. doi: 10.3390/ijms242216255. Int J Mol Sci. 2023. PMID: 38003445 Free PMC article. Review.

See all "Cited by" articles

References

1. Guo JY, Xia B, White E. Autophagy-mediated tumor promotion. Cell. 2013;155:1216–1219. doi:10.1016/j.cell.2013.11.019. PMID:24315093 - DOI - PMC - PubMed
1. Qu X, Yu J, Bhagat G, et al. . Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J Clin Invest. 2003;112:1809–1820. doi:10.1172/JCI20039. PMID:14638851 - DOI - PMC - PubMed
1. Yue Z, Jin S, Yang C, et al. . Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc Natl Acad Sci USA. 2003;100:15077–15082. doi:10.1073/pnas.2436255100. PMID:14657337 - DOI - PMC - PubMed
1. Takahashi Y, Coppola D, Matsushita N, et al. . Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis. Nat Cell Biol. 2007;9:1142–1151. doi:10.1038/ncb1634. PMID:17891140 - DOI - PMC - PubMed
1. Marino G, Salvador-Montoliu N, Fueyo A, et al. . Tissue-specific autophagy alterations and increased tumorigenesis in mice deficient in Atg4C/autophagin-3. J Biol Chem. 2007;282:18573–18583. doi:10.1074/jbc.M701194200. PMID:17442669 - DOI - PubMed

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions
Actions
Actions

Grants and funding

LinkOut - more resources

Full Text Sources
Other Literature Sources
- scite Smart Citations
Research Materials
- NCI CPTC Antibody Characterization Program
Miscellaneous
- NCI CPTAC Assay Portal

[1] Guo JY, Xia B, White E. Autophagy-mediated tumor promotion. Cell. 2013;155:1216–1219. doi:10.1016/j.cell.2013.11.019. PMID:24315093 - DOI - PMC - PubMed

[2] Guo JY, Xia B, White E. Autophagy-mediated tumor promotion. Cell. 2013;155:1216–1219. doi:10.1016/j.cell.2013.11.019. PMID:24315093 - DOI - PMC - PubMed

[3] Qu X, Yu J, Bhagat G, et al. . Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J Clin Invest. 2003;112:1809–1820. doi:10.1172/JCI20039. PMID:14638851 - DOI - PMC - PubMed

[4] Qu X, Yu J, Bhagat G, et al. . Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J Clin Invest. 2003;112:1809–1820. doi:10.1172/JCI20039. PMID:14638851 - DOI - PMC - PubMed

[5] Yue Z, Jin S, Yang C, et al. . Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc Natl Acad Sci USA. 2003;100:15077–15082. doi:10.1073/pnas.2436255100. PMID:14657337 - DOI - PMC - PubMed

[6] Yue Z, Jin S, Yang C, et al. . Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc Natl Acad Sci USA. 2003;100:15077–15082. doi:10.1073/pnas.2436255100. PMID:14657337 - DOI - PMC - PubMed

[7] Takahashi Y, Coppola D, Matsushita N, et al. . Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis. Nat Cell Biol. 2007;9:1142–1151. doi:10.1038/ncb1634. PMID:17891140 - DOI - PMC - PubMed

[8] Takahashi Y, Coppola D, Matsushita N, et al. . Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis. Nat Cell Biol. 2007;9:1142–1151. doi:10.1038/ncb1634. PMID:17891140 - DOI - PMC - PubMed

[9] Marino G, Salvador-Montoliu N, Fueyo A, et al. . Tissue-specific autophagy alterations and increased tumorigenesis in mice deficient in Atg4C/autophagin-3. J Biol Chem. 2007;282:18573–18583. doi:10.1074/jbc.M701194200. PMID:17442669 - DOI - PubMed

[10] Marino G, Salvador-Montoliu N, Fueyo A, et al. . Tissue-specific autophagy alterations and increased tumorigenesis in mice deficient in Atg4C/autophagin-3. J Biol Chem. 2007;282:18573–18583. doi:10.1074/jbc.M701194200. PMID:17442669 - DOI - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

A PINK1-mediated mitophagy pathway decides the fate of tumors-to be benign or malignant?

Affiliation

A PINK1-mediated mitophagy pathway decides the fate of tumors-to be benign or malignant?

Authors

Affiliation

Abstract

Similar articles

Cited by

References

Publication types

MeSH terms

Substances

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Research Materials

Miscellaneous

Abstract

Similar articles

Cited by

References

Publication types

MeSH terms

Substances

Related information

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Research Materials

Miscellaneous