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. 2018;14(4):715-716.

doi: 10.1080/15548627.2018.1425058. Epub 2018 Feb 21.

Mitophagy and hepatic cancer stem cells

Jiyoung Lee¹, Kai Liu^{1

2

3}, Bangyan Stiles⁴, Jing-Hsiung James Ou¹

Affiliations

Affiliations

¹ a Department of Molecular Microbiology and Immunology, Keck School of Medicine , University of Southern California , Los Angeles , CA , USA.
² b Beijing You'an Hospital , Capital Medical University , Beijing , China.
³ c Beijing Institute of Hepatology , Beijing , China.
⁴ d Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy , University of Southern California , Los Angeles , CA , USA.

PMID: 29313421
PMCID: PMC5959321
DOI: 10.1080/15548627.2018.1425058

Mitophagy and hepatic cancer stem cells

Jiyoung Lee et al. Autophagy. 2018.

. 2018;14(4):715-716.

doi: 10.1080/15548627.2018.1425058. Epub 2018 Feb 21.

Authors

Jiyoung Lee¹, Kai Liu^{1

2

3}, Bangyan Stiles⁴, Jing-Hsiung James Ou¹

Affiliations

¹ a Department of Molecular Microbiology and Immunology, Keck School of Medicine , University of Southern California , Los Angeles , CA , USA.
² b Beijing You'an Hospital , Capital Medical University , Beijing , China.
³ c Beijing Institute of Hepatology , Beijing , China.
⁴ d Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy , University of Southern California , Los Angeles , CA , USA.

PMID: 29313421
PMCID: PMC5959321
DOI: 10.1080/15548627.2018.1425058

No abstract available

Keywords: NANOG; PINK1; autophagy; cancer stem cells; hepatocarcinogenesis; mitophagy; p53.

PubMed Disclaimer

Figures

Figure 1. — Figure 1.
Model of how mitophagy regulates CSCs. When mitophagy is impaired (left panel), PINK1 phosphorylates TP53 at S392, likely on mitochondria, resulting in the activation and nuclear localization of TP53. TP53 then suppresses the expression of NANOG and reduces the self-renewal ability of CSCs. When mitophagy is enhanced (right panel), TP53 associated with PINK1 on mitochondria is degraded with mitochondria in autophagic vacuoles. This leads to the induction of NANOG expression by POU5F1/OCT4 and SOX2, and the enhancement of self-renewal of CSCs.

See this image and copyright information in PMC

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