Glucose-Sensing in the Reward System

doi:10.3389/fnins.2017.00716

Review

. 2017 Dec 19:11:716.

doi: 10.3389/fnins.2017.00716. eCollection 2017.

Glucose-Sensing in the Reward System

Laura L Koekkoek^{1

2

3}, Joram D Mul^{1

2

3}, Susanne E la Fleur^{1

2

3}

Affiliations

¹ Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.
² Laboratory of Endocrinology, Department of Clinical Chemistry, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.
³ Metabolism and Reward Group, Netherlands Institute for Neuroscience, Institute of the Royal Netherlands Academy of Arts and Sciences (KNAW), Amsterdam, Netherlands.

PMID: 29311793
PMCID: PMC5742113
DOI: 10.3389/fnins.2017.00716

Review

Glucose-Sensing in the Reward System

Laura L Koekkoek et al. Front Neurosci. 2017.

. 2017 Dec 19:11:716.

doi: 10.3389/fnins.2017.00716. eCollection 2017.

Authors

Laura L Koekkoek^{1

2

3}, Joram D Mul^{1

2

3}, Susanne E la Fleur^{1

2

3}

Affiliations

¹ Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.
² Laboratory of Endocrinology, Department of Clinical Chemistry, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.
³ Metabolism and Reward Group, Netherlands Institute for Neuroscience, Institute of the Royal Netherlands Academy of Arts and Sciences (KNAW), Amsterdam, Netherlands.

PMID: 29311793
PMCID: PMC5742113
DOI: 10.3389/fnins.2017.00716

Abstract

Glucose-sensing neurons are neurons that alter their activity in response to changes in extracellular glucose. These neurons, which are an important mechanism the brain uses to monitor changes in glycaemia, are present in the hypothalamus, where they have been thoroughly investigated. Recently, glucose-sensing neurons have also been identified in brain nuclei which are part of the reward system. However, little is known about the molecular mechanisms by which they function, and their role in the reward system. We therefore aim to provide an overview of molecular mechanisms that have been studied in the hypothalamic glucose-sensing neurons, and investigate which of these transporters, enzymes and channels are present in the reward system. Furthermore, we speculate about the role of glucose-sensing neurons in the reward system.

Keywords: GLUT; SGLT; amygdala; nucleus accumbens; reward.

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References

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1. Arluison M., Quignon M., Nguyen P., Thorens B., Leloup C., Penicaud L. (2004). Distribution and anatomical localization of the glucose transporter 2 (GLUT2) in the adult rat brain–an immunohistochemical study. J. Chem. Neuroanat. 28, 117–136. 10.1016/j.jchemneu.2004.05.009 - DOI - PubMed
1. Aston-Jones G., Smith R. J., Moorman D. E., Richardson K. A. (2009). Role of lateral hypothalamic orexin neurons in reward processing and addiction. Neuropharmacology 56(Suppl. 1), 112–121. 10.1016/j.neuropharm.2008.06.060 - DOI - PMC - PubMed

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[1] Aberman J. E., Ward S. J., Salamone J. D. (1998). Effects of dopamine antagonists and accumbens dopamine depletions on time-constrained progressive-ratio performance. Pharmacol. Biochem. Behav. 61, 341–348. 10.1016/S0091-3057(98)00112-9 - DOI - PubMed

[2] Aberman J. E., Ward S. J., Salamone J. D. (1998). Effects of dopamine antagonists and accumbens dopamine depletions on time-constrained progressive-ratio performance. Pharmacol. Biochem. Behav. 61, 341–348. 10.1016/S0091-3057(98)00112-9 - DOI - PubMed

[3] Abizaid A., Liu Z. W., Andrews Z. B., Shanabrough M., Borok E., Elsworth J. D., et al. . (2006). Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite. J. Clin. Invest. 116, 3229–3239. 10.1172/JCI29867 - DOI - PMC - PubMed

[4] Abizaid A., Liu Z. W., Andrews Z. B., Shanabrough M., Borok E., Elsworth J. D., et al. . (2006). Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite. J. Clin. Invest. 116, 3229–3239. 10.1172/JCI29867 - DOI - PMC - PubMed

[5] Aljure O., Diez-Sampedro A. (2010). Functional characterization of mouse sodium/glucose transporter type 3b. Am. J. Physiol. Cell Physiol. 299, C58–C65. 10.1152/ajpcell.00030.2010 - DOI - PubMed

[6] Aljure O., Diez-Sampedro A. (2010). Functional characterization of mouse sodium/glucose transporter type 3b. Am. J. Physiol. Cell Physiol. 299, C58–C65. 10.1152/ajpcell.00030.2010 - DOI - PubMed

[7] Arluison M., Quignon M., Nguyen P., Thorens B., Leloup C., Penicaud L. (2004). Distribution and anatomical localization of the glucose transporter 2 (GLUT2) in the adult rat brain–an immunohistochemical study. J. Chem. Neuroanat. 28, 117–136. 10.1016/j.jchemneu.2004.05.009 - DOI - PubMed

[8] Arluison M., Quignon M., Nguyen P., Thorens B., Leloup C., Penicaud L. (2004). Distribution and anatomical localization of the glucose transporter 2 (GLUT2) in the adult rat brain–an immunohistochemical study. J. Chem. Neuroanat. 28, 117–136. 10.1016/j.jchemneu.2004.05.009 - DOI - PubMed

[9] Aston-Jones G., Smith R. J., Moorman D. E., Richardson K. A. (2009). Role of lateral hypothalamic orexin neurons in reward processing and addiction. Neuropharmacology 56(Suppl. 1), 112–121. 10.1016/j.neuropharm.2008.06.060 - DOI - PMC - PubMed

[10] Aston-Jones G., Smith R. J., Moorman D. E., Richardson K. A. (2009). Role of lateral hypothalamic orexin neurons in reward processing and addiction. Neuropharmacology 56(Suppl. 1), 112–121. 10.1016/j.neuropharm.2008.06.060 - DOI - PMC - PubMed

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Glucose-Sensing in the Reward System

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Glucose-Sensing in the Reward System

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