Voltage-gated and stretch-activated potassium channels in the human heart : Pathophysiological and clinical significance

doi:10.1007/s00399-017-0541-z

Review

. 2018 Mar;29(1):36-42.

doi: 10.1007/s00399-017-0541-z. Epub 2018 Jan 5.

Voltage-gated and stretch-activated potassium channels in the human heart : Pathophysiological and clinical significance

Constanze Schmidt^{1

2}, Rémi Peyronnet³

Affiliations

¹ Department of Cardiology, University of Heidelberg, Heidelberg, Germany.
² DZHK (German Center for Cardiovascular Research), partner site Heidelberg/Mannheim, University of Heidelberg, Heidelberg, Germany.
³ Institute for Experimental Cardiovascular Medicine, University Heart Center, Medical Center - University of Freiburg, and Faculty of Medicine, University of Freiburg, Elsässer Straße 2q, 79110, Freiburg, Germany. remi.peyronnet@universitaets-herzzentrum.de.

PMID: 29305705
DOI: 10.1007/s00399-017-0541-z

Review

Voltage-gated and stretch-activated potassium channels in the human heart : Pathophysiological and clinical significance

Constanze Schmidt et al. Herzschrittmacherther Elektrophysiol. 2018 Mar.

. 2018 Mar;29(1):36-42.

doi: 10.1007/s00399-017-0541-z. Epub 2018 Jan 5.

Authors

Constanze Schmidt^{1

2}, Rémi Peyronnet³

Affiliations

¹ Department of Cardiology, University of Heidelberg, Heidelberg, Germany.
² DZHK (German Center for Cardiovascular Research), partner site Heidelberg/Mannheim, University of Heidelberg, Heidelberg, Germany.
³ Institute for Experimental Cardiovascular Medicine, University Heart Center, Medical Center - University of Freiburg, and Faculty of Medicine, University of Freiburg, Elsässer Straße 2q, 79110, Freiburg, Germany. remi.peyronnet@universitaets-herzzentrum.de.

PMID: 29305705
DOI: 10.1007/s00399-017-0541-z

Abstract

Ion channels are essential for electrical signaling and contractility in cardiomyocytes. Detailed knowledge about the molecular function and regulation of cardiac ion channels is crucial for understanding cardiac physiology and pathophysiology especially in the field of arrhythmias. This review aims at providing a general overview on the identity, functional characteristics, and roles of voltage-gated as well as stretch-activated potassium selective channels in the heart. In particular, we will highlight potential therapeutic targets as well as the emerging fields of future investigations.

Keywords: Arrhythmias; Cardiac diseases; Drug target; Mechano-transduction; Remodeling.

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[1] Nature. 2010 Jul 8;466(7303):263-6 - PubMed

[2] Nature. 2010 Jul 8;466(7303):263-6 - PubMed

[3] EMBO Mol Med. 2017 Apr;9(4):403-414 - PubMed

[4] EMBO Mol Med. 2017 Apr;9(4):403-414 - PubMed

[5] Naunyn Schmiedebergs Arch Pharmacol. 2012 Oct;385(10):1003-16 - PubMed

[6] Naunyn Schmiedebergs Arch Pharmacol. 2012 Oct;385(10):1003-16 - PubMed

[7] Nature. 2001 Apr 26;410(6832):1120-4 - PubMed

[8] Nature. 2001 Apr 26;410(6832):1120-4 - PubMed

[9] Circ Res. 2002 Mar 22;90(5):586-93 - PubMed

[10] Circ Res. 2002 Mar 22;90(5):586-93 - PubMed

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Voltage-gated and stretch-activated potassium channels in the human heart : Pathophysiological and clinical significance

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Voltage-gated and stretch-activated potassium channels in the human heart : Pathophysiological and clinical significance

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