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. 2018 May;33(5):847-853.
doi: 10.1007/s00467-017-3865-3. Epub 2018 Jan 2.

Evaluation of the level of dynamic thiol/disulphide homeostasis in adolescent patients with newly diagnosed primary hypertension

Evrim Kargın Çakıcı  1 , Fehime Kara Eroğlu  2 , Fatma Yazılıtaş  2 , Mehmet Bülbül  2 , Gökçe Gür  2 , Özlem Aydoğ  3 , Tülin Güngör  2 , Özcan Erel  4 , Murat Alışık  4 , Atilla Halil Elhan  5
Affiliations

Evaluation of the level of dynamic thiol/disulphide homeostasis in adolescent patients with newly diagnosed primary hypertension

Evrim Kargın Çakıcı et al. Pediatr Nephrol. 2018 May.

Erratum in

Abstract

Background: Thiol/disulphide homeostasis plays a critical role in numerous intracellular enzymatic pathways including antioxidant defense and detoxification. This study was designed to investigate the impact of thiol/disulfide homeostasis in adolescent patients with recently diagnosed primary hypertension (HT) using a novel and automated method.

Methods: Native thiol/disulphide levels were measured by a novel spectrophotometric method (Cobasc 501, Roche Diagnostics, Mannheim, Germany) in 30 patients with primary HT together with 30 healthy controls.

Results: The levels of native thiol, total thiol, and native thiol/total thiol ratios were significantly lower, while the disulphide level, disulphide/native thiol, and disulphide/total thiol ratios were significantly higher in patients with primary HT compared with the control group. There were significant positive correlations between 24-h mean systolic and diastolic blood pressure and disulphide levels, disulphide/native thiol, and disulphide/total thiol ratios. A multiple linear regression model showed that a disulphide/native thiol ratio above 5 and family history of HT are independent predictors of HT.

Conclusions: Our study showed that dynamic thiol/disulphide homeostasis shifted towards disulphide formation in adolescent patients with primary HT. Understanding the role of thiol/disulfide homeostasis in primary HT might provide new therapeutic intervention strategies for patients.

Keywords: Adolescents; Blood pressure; Dynamic thiol/disulphide; Oxidative stress; Oxidized thiol.

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