Current Approaches to Bone Tissue Engineering: The Interface between Biology and Engineering

doi:10.1002/adhm.201701061

Review

. 2018 Mar;7(6):e1701061.

doi: 10.1002/adhm.201701061. Epub 2017 Dec 27.

Current Approaches to Bone Tissue Engineering: The Interface between Biology and Engineering

Jiao Jiao Li^{1

2}, Mohamed Ebied³, Jen Xu³, Hala Zreiqat^{1

3}

Affiliations

¹ Biomaterials and Tissue Engineering Research Unit, School of Aerospace, Mechanical and Mechatronic Engineering, University of Sydney, Sydney, NSW, 2006, Australia.
² Raymond Purves Bone and Joint Research Laboratories, Kolling Institute, Northern Sydney Local Health District, Sydney Medical School Northern, University of Sydney, St Leonards, NSW, 2065, Australia.
³ Radcliffe Institute for Advanced Study, Harvard University, Cambridge, MA, 02138, USA.

PMID: 29280321
DOI: 10.1002/adhm.201701061

Review

Current Approaches to Bone Tissue Engineering: The Interface between Biology and Engineering

Jiao Jiao Li et al. Adv Healthc Mater. 2018 Mar.

. 2018 Mar;7(6):e1701061.

doi: 10.1002/adhm.201701061. Epub 2017 Dec 27.

Authors

Jiao Jiao Li^{1

2}, Mohamed Ebied³, Jen Xu³, Hala Zreiqat^{1

3}

Affiliations

¹ Biomaterials and Tissue Engineering Research Unit, School of Aerospace, Mechanical and Mechatronic Engineering, University of Sydney, Sydney, NSW, 2006, Australia.
² Raymond Purves Bone and Joint Research Laboratories, Kolling Institute, Northern Sydney Local Health District, Sydney Medical School Northern, University of Sydney, St Leonards, NSW, 2065, Australia.
³ Radcliffe Institute for Advanced Study, Harvard University, Cambridge, MA, 02138, USA.

PMID: 29280321
DOI: 10.1002/adhm.201701061

Abstract

The successful regeneration of bone tissue to replace areas of bone loss in large defects or at load-bearing sites remains a significant clinical challenge. Over the past few decades, major progress is achieved in the field of bone tissue engineering to provide alternative therapies, particularly through approaches that are at the interface of biology and engineering. To satisfy the diverse regenerative requirements of bone tissue, the field moves toward highly integrated approaches incorporating the knowledge and techniques from multiple disciplines, and typically involves the use of biomaterials as an essential element for supporting or inducing bone regeneration. This review summarizes the types of approaches currently used in bone tissue engineering, beginning with those primarily based on biology or engineering, and moving into integrated approaches in the areas of biomaterial developments, biomimetic design, and scalable methods for treating large or load-bearing bone defects, while highlighting potential areas for collaboration and providing an outlook on future developments.

Keywords: biomaterials; bone regeneration; scaffolds; tissue engineering.

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Current Approaches to Bone Tissue Engineering: The Interface between Biology and Engineering

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Current Approaches to Bone Tissue Engineering: The Interface between Biology and Engineering

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