Uric acid and cardiovascular risk: What genes can say
- PMID: 29250870
- DOI: 10.1111/ijcp.13048
Uric acid and cardiovascular risk: What genes can say
Abstract
Background: Although the relationship of elevated serum uric acid levels and cardiovascular disease has been established in a great number of studies, the causal relevance of this finding remains ambiguous. An approach to evaluate the causal relevance of biomarkers is to exploit the natural randomised allocation of allelic variation in genes affecting their level, also known as Mendelian randomisation.
Aim: The aim of this paper is to review the current literature regarding serum uric acid levels and cardiovascular and renal disease risk in Mendelian randomisation studies.
Methods: PubMed and Scopus databases were searched to retrieve Mendelian studies regarding uric acid, hyperuricaemia and cardiovascular risk.
Conclusions: Genetic evidence based on conventional and novel Mendelian randomisation approaches suggest a modest, if any, causal effect of serum uric acid concentration on the development of cardiovascular disease, suggesting that further study of uric acid genes is needed in order to elucidate the relationship of serum uric acid levels and cardiovascular disease.
© 2017 John Wiley & Sons Ltd.
Similar articles
-
Genetically Determined Uric Acid and the Risk of Cardiovascular and Neurovascular Diseases: A Mendelian Randomization Study of Outcomes Investigated in Randomized Trials.J Am Heart Assoc. 2019 Sep 3;8(17):e012738. doi: 10.1161/JAHA.119.012738. Epub 2019 Aug 23. J Am Heart Assoc. 2019. PMID: 31438759 Free PMC article.
-
Uric Acid and Cardiovascular Events: A Mendelian Randomization Study.J Am Soc Nephrol. 2015 Nov;26(11):2831-8. doi: 10.1681/ASN.2014070660. Epub 2015 Mar 18. J Am Soc Nephrol. 2015. PMID: 25788527 Free PMC article.
-
Serum uric acid, body mass index, and cardiovascular diseases: A multiple two-step Mendelian randomization study.Nutr Metab Cardiovasc Dis. 2024 Oct;34(10):2386-2394. doi: 10.1016/j.numecd.2024.05.023. Epub 2024 May 31. Nutr Metab Cardiovasc Dis. 2024. PMID: 39097442
-
Time to target uric acid to retard CKD progression.Clin Exp Nephrol. 2017 Apr;21(2):182-192. doi: 10.1007/s10157-016-1288-2. Epub 2016 Jun 23. Clin Exp Nephrol. 2017. PMID: 27339448 Review.
-
[Uric acid--more deleterious than we thought?].Tidsskr Nor Laegeforen. 2005 May 19;125(10):1330-2. Tidsskr Nor Laegeforen. 2005. PMID: 15909004 Review. Norwegian.
Cited by
-
Major Left Bundle Branch Block and Coronary Heart Disease-Are There Any Differences between the Sexes?J Clin Med. 2021 May 25;10(11):2284. doi: 10.3390/jcm10112284. J Clin Med. 2021. PMID: 34070288 Free PMC article.
-
Hyperuricemia and its related diseases: mechanisms and advances in therapy.Signal Transduct Target Ther. 2024 Aug 28;9(1):212. doi: 10.1038/s41392-024-01916-y. Signal Transduct Target Ther. 2024. PMID: 39191722 Free PMC article. Review.
-
Uric Acid and Hypertension: Prognostic Role and Guide for Treatment.J Clin Med. 2021 Jan 24;10(3):448. doi: 10.3390/jcm10030448. J Clin Med. 2021. PMID: 33498870 Free PMC article. Review.
-
The Interaction Between Dietary Fructose and Gut Microbiota in Hyperuricemia and Gout.Front Nutr. 2022 Jun 22;9:890730. doi: 10.3389/fnut.2022.890730. eCollection 2022. Front Nutr. 2022. PMID: 35811965 Free PMC article. Review.
-
Influence of Genetic and Non-Genetic Risk Factors for Serum Uric Acid Levels and Hyperuricemia in Mexicans.Nutrients. 2019 Jun 14;11(6):1336. doi: 10.3390/nu11061336. Nutrients. 2019. PMID: 31207883 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources