Organoids: An intermediate modeling platform in precision oncology

doi:10.1016/j.canlet.2017.11.021

Review

. 2018 Feb 1:414:174-180.

doi: 10.1016/j.canlet.2017.11.021. Epub 2017 Nov 22.

Organoids: An intermediate modeling platform in precision oncology

Ming-Zhu Jin¹, Run-Run Han², Guan-Zhong Qiu³, Xiang-Chun Ju⁴, Ge Lou⁵, Wei-Lin Jin⁶

Affiliations

¹ Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, PR China.
² Department of Pulmonary Circulation, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433, PR China.
³ Department of Neurosurgery, General Hospital of Jinan Military Command, Jinan 250031, PR China.
⁴ Institute of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, PR China. Electronic address: xcju@ion.ac.cn.
⁵ Department of Gynecology Oncology, The Tumor Hospital, Harbin Medical University, Harbin, 150086, PR China. Electronic address: louge@ems.hrbmu.edu.cn.
⁶ Institute of Nano Biomedicine and Engineering, Shanghai Engineering Center for Intelligent Diagnosis and Treatment Instrument, Department of Instrument Science and Engineering, Key Laboratory for Thin Film and Microfabrication Technology of Ministry of Education, School of Electronic Information and Electronic Engineering, Shanghai Jiao Tong University, Shanghai 200240, PR China; National Center for Translational Medicine, Collaborative Innovational Center for System Biology, Shanghai Jiao Tong University, Shanghai 200240, PR China; Shaanxi Key Laboratory of Brain Disorders and School of Basic Medical Sciences, Xi'an Medical University, Xi'an 710021, PR China. Electronic address: weilinjin@yahoo.com.

PMID: 29174804
DOI: 10.1016/j.canlet.2017.11.021

Review

Organoids: An intermediate modeling platform in precision oncology

Ming-Zhu Jin et al. Cancer Lett. 2018.

. 2018 Feb 1:414:174-180.

doi: 10.1016/j.canlet.2017.11.021. Epub 2017 Nov 22.

Authors

Ming-Zhu Jin¹, Run-Run Han², Guan-Zhong Qiu³, Xiang-Chun Ju⁴, Ge Lou⁵, Wei-Lin Jin⁶

Affiliations

¹ Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, PR China.
² Department of Pulmonary Circulation, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433, PR China.
³ Department of Neurosurgery, General Hospital of Jinan Military Command, Jinan 250031, PR China.
⁴ Institute of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, PR China. Electronic address: xcju@ion.ac.cn.
⁵ Department of Gynecology Oncology, The Tumor Hospital, Harbin Medical University, Harbin, 150086, PR China. Electronic address: louge@ems.hrbmu.edu.cn.
⁶ Institute of Nano Biomedicine and Engineering, Shanghai Engineering Center for Intelligent Diagnosis and Treatment Instrument, Department of Instrument Science and Engineering, Key Laboratory for Thin Film and Microfabrication Technology of Ministry of Education, School of Electronic Information and Electronic Engineering, Shanghai Jiao Tong University, Shanghai 200240, PR China; National Center for Translational Medicine, Collaborative Innovational Center for System Biology, Shanghai Jiao Tong University, Shanghai 200240, PR China; Shaanxi Key Laboratory of Brain Disorders and School of Basic Medical Sciences, Xi'an Medical University, Xi'an 710021, PR China. Electronic address: weilinjin@yahoo.com.

PMID: 29174804
DOI: 10.1016/j.canlet.2017.11.021

Abstract

Cancer harbors variable heterogeneity and plasticity. Thus far, our comprehension is greatly based on cell lines, organoids, and patient-derived tumor xenografts (PDTXs). Organoids are a three-dimensional in vitro culture platform constructed from self-organizing stem cells. They can almost accurately recapitulate tumor heterogeneity and microenvironment "in a dish," which surpass established cell lines and are not as expensive and time-consuming as PDTXs. As an intermediate model, tumor organoids are also used to study the fundamental issues of tumorigenesis and metastasis. They are specifically applied for drug testing and stored as "living biobanks." In this review, we highlight the translational applications of organoid technologies in tumor research and precision medicine, discuss the advantages and limitations compared with other mentioned methods, and provide our outlook on its future.

Keywords: 3D culture technology; Cancer; Organoids; Precision oncology; Tumor heterogeneity.

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Organoids: An intermediate modeling platform in precision oncology

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Organoids: An intermediate modeling platform in precision oncology

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