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Review
. 2018 Feb:41:15-20.
doi: 10.1016/j.mib.2017.11.006. Epub 2017 Dec 19.

Lifestyle transitions and adaptive pathogenesis of Pseudomonas aeruginosa

Martina Valentini  1 , Diego Gonzalez  2 , Despoina Ai Mavridou  3 , Alain Filloux  4
Affiliations
Free article
Review

Lifestyle transitions and adaptive pathogenesis of Pseudomonas aeruginosa

Martina Valentini et al. Curr Opin Microbiol. 2018 Feb.
Free article

Abstract

Pseudomonas aeruginosa acute and chronic infections are of great concern to human health, especially in hospital settings. It is currently assumed that P. aeruginosa has two antagonistic pathogenic strategies that parallel two different lifestyles; free-living cells are predominantly cytotoxic and induce an acute inflammatory reaction, while biofilm-forming communities cause refractory chronic infections. Recent findings suggest that the planktonic-to-sessile transition is a complex, reversible and overall dynamic differentiation process. Here, we examine how the Gac/Rsm regulatory cascade, a key player in this lifestyle switch, endows P. aeruginosa with both a permissive lifecycle in nature and flexible virulence strategy during infection.

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