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Case Reports
. 2017 Sep 1;52(3):169-172.
doi: 10.5152/TurkPediatriArs.2017.2956. eCollection 2017 Sep.

Plasmapheresis in a child with cold antibody autoimmune hemolytic anemia: case report

Zeynep Canan Özdemir  1 , Özcan Bör  1 , Ener Çağrı Dinleyici  2 , Eylem Kıral  2
Affiliations
Case Reports

Plasmapheresis in a child with cold antibody autoimmune hemolytic anemia: case report

Zeynep Canan Özdemir et al. Turk Pediatri Ars. .

Abstract

Autoimmune hemolytic anemia is a picture of hemolysis which is caused by autoantibodies against red blood cell surface antigens. It is classified as primary, secondary or warm and cold autoimmune hemolytic anemia according to the temperature at which antibodies react. It is usually an acute and self-limiting condition. Here, we present a three-year-old male patient who presented with malaise, paleness, and dark-colored urine. His hemoglobin level was 5.8 g/dL, and increased indirect bilirubin and lactate dehydrogenase levels and decreased haptoglobulin and reticulocyte levels were noted. A direct Coombs test was positive using anti-C3. Four erythrocyte suspension transfusions were given because the anemia was life-threatening. High-dose steroids (30 mg/kg/ day, methylprednisolone) and intravenous immunoglobulin (1 g/kg/day, two days) treatments were unresponsive. Plasmapheresis was performed and no further transfusions were needed after plasmapheresis. Plasmapheresis treatment can be effective in children with cold type autoimmune hemolytic anemia.

Keywords: Autoimmune hemolytic anemia; cold antibody; plasmapheresis.

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Conflict of interest statement

Conflict of Interest: No conflict of interest was declared by the authors.

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