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Review
. 2018 Feb;98(2):190-197.
doi: 10.1038/labinvest.2017.103. Epub 2017 Oct 16.

Regulation of heterotrimeric G-protein signaling by NDPK/NME proteins and caveolins: an update

Issam H Abu-Taha  1 , Jordi Heijman  2 , Yuxi Feng  3 , Christiane Vettel  3   4 , Dobromir Dobrev  1 , Thomas Wieland  3   4
Affiliations
Free article
Review

Regulation of heterotrimeric G-protein signaling by NDPK/NME proteins and caveolins: an update

Issam H Abu-Taha et al. Lab Invest. 2018 Feb.
Free article

Abstract

Heterotrimeric G proteins are pivotal mediators of cellular signal transduction in eukaryotic cells and abnormal G-protein signaling plays an important role in numerous diseases. During the last two decades it has become evident that the activation status of heterotrimeric G proteins is both highly localized and strongly regulated by a number of factors, including a receptor-independent activation pathway of heterotrimeric G proteins that does not involve the classical GDP/GTP exchange and relies on nucleoside diphosphate kinases (NDPKs). NDPKs are NTP/NDP transphosphorylases encoded by the nme/nm23 genes that are involved in a variety of cellular events such as proliferation, migration, and apoptosis. They therefore contribute, for example, to tumor metastasis, angiogenesis, retinopathy, and heart failure. Interestingly, NDPKs are translocated and/or upregulated in human heart failure. Here we describe recent advances in the current understanding of NDPK functions and how they have an impact on local regulation of G-protein signaling.

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