Formation of New Cardiomyocytes in Exercise

doi:10.1007/978-981-10-4307-9_6

Review

. 2017:999:91-102.

doi: 10.1007/978-981-10-4307-9_6.

Formation of New Cardiomyocytes in Exercise

Liang Shen¹, Hui Wang², Yihua Bei³, Dragos Cretoiu^{4

5}, Sanda Maria Cretoiu^{4

5}, Junjie Xiao⁶

Affiliations

¹ Physical Education College of Shanghai University, Shanghai, 200444, China.
² Department of Cardiology, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, China.
³ Cardiac Regeneration and Ageing Lab, School of Life Science, Shanghai University, Shanghai, 200444, China.
⁴ Victor Babes National Institute of Pathology, Bucharest, 050096, Romania.
⁵ Division of Cellular and Molecular Biology and Histology, Carol Davila University of Medicine and Pharmacy, Bucharest, 050474, Romania.
⁶ Cardiac Regeneration and Ageing Lab, School of Life Science, Shanghai University, Shanghai, 200444, China. junjiexiao@shu.edu.cn.

PMID: 29022259
DOI: 10.1007/978-981-10-4307-9_6

Review

Formation of New Cardiomyocytes in Exercise

Liang Shen et al. Adv Exp Med Biol. 2017.

. 2017:999:91-102.

doi: 10.1007/978-981-10-4307-9_6.

Authors

Liang Shen¹, Hui Wang², Yihua Bei³, Dragos Cretoiu^{4

5}, Sanda Maria Cretoiu^{4

5}, Junjie Xiao⁶

Affiliations

¹ Physical Education College of Shanghai University, Shanghai, 200444, China.
² Department of Cardiology, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, China.
³ Cardiac Regeneration and Ageing Lab, School of Life Science, Shanghai University, Shanghai, 200444, China.
⁴ Victor Babes National Institute of Pathology, Bucharest, 050096, Romania.
⁵ Division of Cellular and Molecular Biology and Histology, Carol Davila University of Medicine and Pharmacy, Bucharest, 050474, Romania.
⁶ Cardiac Regeneration and Ageing Lab, School of Life Science, Shanghai University, Shanghai, 200444, China. junjiexiao@shu.edu.cn.

PMID: 29022259
DOI: 10.1007/978-981-10-4307-9_6

Abstract

Heart failure is a life-threatening disorder associated with the loss of cardiomyocytes. The heart has some endogenous although limited regenerative capacity, thus enhancing cardiac regeneration or stimulating endogenous repair mechanism after cardiac injury is of great interest. The benefits of exercise in heart diseases have been recognized for centuries. Besides the promotion of a favorable cardiac function, exercise is also associated with new cardiomyocytes formation. Exercise may lead to cardiomyocytes renewal from pre-existing cardiomyocytes proliferation or cardiac stem/progenitor cells differentiation. A deep understanding of exercise-induced formation of new cardiomyocytes will enable us to develop novel therapeutics for heart diseases.

Keywords: Cardiomyocytes; Exercise; Progenitor cells; Proliferation; Stem cells.

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Formation of New Cardiomyocytes in Exercise

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Formation of New Cardiomyocytes in Exercise

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