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Review
. 2018;14(1):3-21.
doi: 10.1080/15548627.2017.1384887. Epub 2017 Nov 23.

Ion channels in the regulation of autophagy

Artem Kondratskyi  1 , Kateryna Kondratska  1 , Roman Skryma  1 , Daniel J Klionsky  2 , Natalia Prevarskaya  1
Affiliations
Review

Ion channels in the regulation of autophagy

Artem Kondratskyi et al. Autophagy. 2018.

Abstract

Autophagy is a cellular process in which the cell degrades and recycles its own constituents. Given the crucial role of autophagy in physiology, deregulation of autophagic machinery is associated with various diseases. Hence, a thorough understanding of autophagy regulatory mechanisms is crucially important for the elaboration of efficient treatments for different diseases. Recently, ion channels, mediating ion fluxes across cellular membranes, have emerged as important regulators of both basal and induced autophagy. However, the mechanisms by which specific ion channels regulate autophagy are still poorly understood, thus underscoring the need for further research in this field. Here we discuss the involvement of major types of ion channels in autophagy regulation.

Keywords: autophagy; calcium; chloride; ion channels; potassium; sodium.

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Figures

Figure 1.
Figure 1.
Ion channels in the regulation of autophagy. Inhibitory and stimulatory actions of various ion channels on autophagy are depicted. Ion channels that stimulate autophagy are shown in green, whereas ion channels that inhibit autophagy are shown in red. Ion channels for which both stimulatory and inhibitory roles have been reported are shown in green/red. For a detailed description, please refer to the specific sections in the text or Table S1.
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