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. 2018 Jan 21:437:58-66.
doi: 10.1016/j.jtbi.2017.09.014. Epub 2017 Sep 18.

Fractal rules in brain networks: Signatures of self-organization

Soibam Shyamchand Singh  1 , Dineshchandra Haobijam  2 , Md Zubbair Malik  1 , Romana Ishrat  3 , R K Brojen Singh  4
Affiliations

Fractal rules in brain networks: Signatures of self-organization

Soibam Shyamchand Singh et al. J Theor Biol. .

Abstract

We study brain network data of three species, namely, C. elegans, cat and macaque monkey within the framework of network theory and Potts Hamiltonian model, and explore rich fractal nature in it, which could be an important signature of self-organization, and a simple rule to be obeyed in complex patterns of brain networks. Further, this fractal behaviors in topological parameters of brain networks at various network levels could be an indicator of systems level organization in complicated brain functionality. Again, Rich-club formation of leading hubs in brain networks becomes unpredictable as one goes down to different levels of organization. The popularity of these leading hubs in main modules or sub-modules also gets changed at different network levels, with varied attitudes at each level. Moreover, distribution of edges, which involves intra- and inter-modular/sub-modular interactions, inherited from one level of organization to another level follows fractal law. In addition to this, the Hamiltonian function at each network level, which may correspond to the energy cost in network organization at that level, shows fractal nature. Significant motifs, which are building blocks of networks and related to basic functionalities, in brain networks is found to be triangular motif, and its probability distribution at various levels as a function of size of modules or sub-modules follows fractal law.

Keywords: Brain network; Fractal; Motif.

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