New Advances and Challenges of Targeting Cancer Stem Cells

doi:10.1158/0008-5472.CAN-17-0054

. 2017 Oct 1;77(19):5222-5227.

doi: 10.1158/0008-5472.CAN-17-0054. Epub 2017 Sep 19.

New Advances and Challenges of Targeting Cancer Stem Cells

Nurmaa K Dashzeveg¹, Rokana Taftaf¹, Erika K Ramos¹, Luke Torre-Healy², Anastasia Chumakova², Daniel J Silver², Tyler J Alban², Maksim Sinyuk², Praveena S Thiagarajan², Awad M Jarrar², Soumya M Turaga², Caner Saygin², Erin Mulkearns-Hubert², Masahiro Hitomi², Jeremy N Rich^{3

4

5}, Stanton L Gerson^{4

5

6}, Justin D Lathia^{2

4

5}, Huiping Liu^{7

4

5

8

9}

Affiliations

¹ Department of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
² Department of Cellular and Molecular Medicine, Cleveland Clinic Lerner Research Institute, Cleveland, Ohio.
³ Department of Stem Cell Biology and Regenerative Medicine, Cleveland Clinic Lerner Research Institute, Cleveland, Ohio.
⁴ The Case Comprehensive Cancer Center, Cleveland, Ohio.
⁵ The National Center for Regenerative Medicine, Cleveland, Ohio.
⁶ The University Hospitals Cleveland Medical Center, Cleveland, Ohio.
⁷ Department of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois. huiping.liu@northwestern.edu.
⁸ Department of Medicine (Hematology and Oncology Division) and Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
⁹ Deparmtent of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio.

PMID: 28928129
PMCID: PMC5833988
DOI: 10.1158/0008-5472.CAN-17-0054

New Advances and Challenges of Targeting Cancer Stem Cells

Nurmaa K Dashzeveg et al. Cancer Res. 2017.

. 2017 Oct 1;77(19):5222-5227.

doi: 10.1158/0008-5472.CAN-17-0054. Epub 2017 Sep 19.

Authors

Affiliations

¹ Department of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
² Department of Cellular and Molecular Medicine, Cleveland Clinic Lerner Research Institute, Cleveland, Ohio.
³ Department of Stem Cell Biology and Regenerative Medicine, Cleveland Clinic Lerner Research Institute, Cleveland, Ohio.
⁴ The Case Comprehensive Cancer Center, Cleveland, Ohio.
⁵ The National Center for Regenerative Medicine, Cleveland, Ohio.
⁶ The University Hospitals Cleveland Medical Center, Cleveland, Ohio.
⁷ Department of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois. huiping.liu@northwestern.edu.
⁸ Department of Medicine (Hematology and Oncology Division) and Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
⁹ Deparmtent of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio.

PMID: 28928129
PMCID: PMC5833988
DOI: 10.1158/0008-5472.CAN-17-0054

Abstract

The second International Cancer Stem Cell Conference in Cleveland, Ohio, on September 20-23, 2016, convened 330 attendees from academic, industrial, and clinical organizations. It featured a debate on the concepts and challenges of the cancer stem cells (CSC) as well as CSC-centered scientific sessions on clinical trials, genetics and epigenetics, tumor microenvironment, immune suppression, metastasis, therapeutic resistance, and emerging novel concepts. The conference hosted 35 renowned speakers, 100 posters, 20 short talks, and a preconference workshop. The reported advances of CSC research and therapies fostered new collaborations across national and international borders, and inspired the next generation's young scientists. Cancer Res; 77(19); 5222-7. ©2017 AACR.

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Conflict of interest statement

Disclosure of Potential Conflicts of Interest

No potential conflicts of interest were disclosed.

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References

1. Lapidot T, Sirard C, Vormoor J, Murdoch B, Hoang T, Caceres-Cortes J, et al. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature. 1994;367:645–8. - PubMed
1. Adorno-Cruz V, Kibria G, Liu X, Doherty M, Junk DJ, Guan D, et al. Cancer stem cells: targeting the roots of cancer, seeds of metastasis, and sources of therapy resistance. Cancer Res. 2015;75:924–9. - PMC - PubMed
1. Ng SW, Mitchell A, Kennedy JA, Chen WC, McLeod J, Ibrahimova N, et al. A 17-gene stemness score for rapid determination of risk in acute leukaemia. Nature. 2016;540:433–7. - PubMed
1. Shlush LI, Zandi S, Mitchell A, Chen WC, Brandwein JM, Gupta V, et al. Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia. Nature. 2014;506:328–33. - PMC - PubMed
1. Guo W, Keckesova Z, Donaher JL, Shibue T, Tischler V, Reinhardt F, et al. Slug and Sox9 cooperatively determine the mammary stem cell state. Cell. 2012;148:1015–28. - PMC - PubMed

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[1] Lapidot T, Sirard C, Vormoor J, Murdoch B, Hoang T, Caceres-Cortes J, et al. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature. 1994;367:645–8. - PubMed

[2] Lapidot T, Sirard C, Vormoor J, Murdoch B, Hoang T, Caceres-Cortes J, et al. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature. 1994;367:645–8. - PubMed

[3] Adorno-Cruz V, Kibria G, Liu X, Doherty M, Junk DJ, Guan D, et al. Cancer stem cells: targeting the roots of cancer, seeds of metastasis, and sources of therapy resistance. Cancer Res. 2015;75:924–9. - PMC - PubMed

[4] Adorno-Cruz V, Kibria G, Liu X, Doherty M, Junk DJ, Guan D, et al. Cancer stem cells: targeting the roots of cancer, seeds of metastasis, and sources of therapy resistance. Cancer Res. 2015;75:924–9. - PMC - PubMed

[5] Ng SW, Mitchell A, Kennedy JA, Chen WC, McLeod J, Ibrahimova N, et al. A 17-gene stemness score for rapid determination of risk in acute leukaemia. Nature. 2016;540:433–7. - PubMed

[6] Ng SW, Mitchell A, Kennedy JA, Chen WC, McLeod J, Ibrahimova N, et al. A 17-gene stemness score for rapid determination of risk in acute leukaemia. Nature. 2016;540:433–7. - PubMed

[7] Shlush LI, Zandi S, Mitchell A, Chen WC, Brandwein JM, Gupta V, et al. Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia. Nature. 2014;506:328–33. - PMC - PubMed

[8] Shlush LI, Zandi S, Mitchell A, Chen WC, Brandwein JM, Gupta V, et al. Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia. Nature. 2014;506:328–33. - PMC - PubMed

[9] Guo W, Keckesova Z, Donaher JL, Shibue T, Tischler V, Reinhardt F, et al. Slug and Sox9 cooperatively determine the mammary stem cell state. Cell. 2012;148:1015–28. - PMC - PubMed

[10] Guo W, Keckesova Z, Donaher JL, Shibue T, Tischler V, Reinhardt F, et al. Slug and Sox9 cooperatively determine the mammary stem cell state. Cell. 2012;148:1015–28. - PMC - PubMed

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New Advances and Challenges of Targeting Cancer Stem Cells

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New Advances and Challenges of Targeting Cancer Stem Cells

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