SUMO proteins: Guardians of immune system

doi:10.1016/j.jaut.2017.09.001

Review

. 2017 Nov:84:21-28.

doi: 10.1016/j.jaut.2017.09.001. Epub 2017 Sep 15.

SUMO proteins: Guardians of immune system

Sabrina Adorisio¹, Alessandra Fierabracci², Isabella Muscari³, Anna Marina Liberati³, Emira Ayroldi¹, Graziella Migliorati¹, Trinh Thi Thuy⁴, Carlo Riccardi¹, Domenico V Delfino⁵

Affiliations

¹ Section of Pharmacology, Department of Medicine, University of Perugia, Piazzale Severi, 06132, Perugia, Italy.
² Type 1 Diabetes Centre, Infectivology and Clinical Trials Research Department, Children's Hospital Bambino Gesù, Rome, Italy.
³ Section of Onco-hematology, University of Perugia, Santa Maria Hospital, 05100, Terni, Italy.
⁴ Institute of Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Nghia Do, Cau Giay, Ha Noi, Viet Nam.
⁵ Section of Pharmacology, Department of Medicine, University of Perugia, Piazzale Severi, 06132, Perugia, Italy; Foligno Nursing School, Via Oberdan 123, Foligno, PG, Italy. Electronic address: domenico.delfino@unipg.it.

PMID: 28919255
DOI: 10.1016/j.jaut.2017.09.001

Review

SUMO proteins: Guardians of immune system

Sabrina Adorisio et al. J Autoimmun. 2017 Nov.

. 2017 Nov:84:21-28.

doi: 10.1016/j.jaut.2017.09.001. Epub 2017 Sep 15.

Authors

Sabrina Adorisio¹, Alessandra Fierabracci², Isabella Muscari³, Anna Marina Liberati³, Emira Ayroldi¹, Graziella Migliorati¹, Trinh Thi Thuy⁴, Carlo Riccardi¹, Domenico V Delfino⁵

Affiliations

¹ Section of Pharmacology, Department of Medicine, University of Perugia, Piazzale Severi, 06132, Perugia, Italy.
² Type 1 Diabetes Centre, Infectivology and Clinical Trials Research Department, Children's Hospital Bambino Gesù, Rome, Italy.
³ Section of Onco-hematology, University of Perugia, Santa Maria Hospital, 05100, Terni, Italy.
⁴ Institute of Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Nghia Do, Cau Giay, Ha Noi, Viet Nam.
⁵ Section of Pharmacology, Department of Medicine, University of Perugia, Piazzale Severi, 06132, Perugia, Italy; Foligno Nursing School, Via Oberdan 123, Foligno, PG, Italy. Electronic address: domenico.delfino@unipg.it.

PMID: 28919255
DOI: 10.1016/j.jaut.2017.09.001

Abstract

Small ubiquitin-like modifier (SUMO) proteins belong to the ubiquitin-like family and act to change the function of target proteins through post-translational modifications. Through their interactions with innate immune pathways, SUMOs promote an efficient immune response to pathogenic challenge avoiding, at the same time, an excess of immune response that could lead to the development of autoimmune diseases. This report discusses the general functions of SUMO proteins; highlights SUMO involvement in the innate immune response through their role in NF-κB and interferon pathways; the involvement of SUMO proteins in autoimmune diseases; and reviews bacterial, viral, and parasitic interactions with SUMO pathways. In conclusion, we speculate that targeting SUMOs could represent a new therapeutic strategy against infections and autoimmunity.

Keywords: Autoimmunity; Innate immune system; Interferon pathway; NF-κB pathway; Small ubiquitin-like modifier (SUMO) proteins.

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SUMO proteins: Guardians of immune system

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