Efficacy of topical Rose (Rosa damascena Mill.) oil for migraine headache: A randomized double-blinded placebo-controlled cross-over trial
- PMID: 28917373
- DOI: 10.1016/j.ctim.2017.07.009
Efficacy of topical Rose (Rosa damascena Mill.) oil for migraine headache: A randomized double-blinded placebo-controlled cross-over trial
Abstract
Aim: To evaluate the effect of topical formulation of Rosa damascena Mill. (R. damascena) oil on migraine headache, applying syndrome diffrentiation model.
Methods and materials: Forty patients with migraine headache were randomly assigned to 2 groups of this double-blind, placebo-controlled cross-over trial. The patients were treated for the first 2 consecutive migraine headache attacks by topical R. damascena oil or placebo. Then, after one week of washout period, cross-over was done. Pain intensity of the patients' migraine headache was recorded at the beginnig and ten-sequence time schadule of attacks up to 24h. In addition, photophobia, phonophobia, and nausea and/or vomitting (N/V) of the patients were recorded as secondary outcomes. Finally, gathered data were analysed in a syndrome differentiation manner to assess the effect of R. damascena oil on Hot- and Cold-type migraine headache.
Results: Mean pain intensity of the patients' migraine headache in the different time-points after R. damascena oil or placebo use, was not significantly different. Additionally, regarding mean scores of N/V, photophobia, and phonophobia severity of the patients, no significant differences between the two groups were observed. Finally, applying syndrome differentiation model, the mean score of migraine headache pain intensity turned out to be significantly lower in patients with "hot" type migraine syndrome at in 30, 45, 60, 90, and 120min after R. damascena oil application compared to "cold" types (P values: 0.001, 0.001, <0.001, <0.001, and 0.02; respectively).
Conclusion: It seems that syndrome differentiation can help in selection of patients who may benefit from the topical R. damascena oil in short-term relief of pain intensity in migraine headache. Further studies of longer follow-up and larger study population, however, are necessitated for more scientifically rigorous judgment on efficacy of R. damascena oil for patients with migraine headache.
Keywords: Headache; Medicinal plants; Migraine disorders; Rosa damascena Mill.; Rose; Traditional Persian medicine.
Copyright © 2017 Elsevier Ltd. All rights reserved.
Similar articles
-
Chemical constituents, experimental and clinical pharmacology of Rosa damascena: a literature review.J Pharm Pharmacol. 2020 Feb;72(2):161-174. doi: 10.1111/jphp.13185. Epub 2019 Nov 11. J Pharm Pharmacol. 2020. PMID: 31709541 Review.
-
A systematic review of the efficacy and safety of Rosa damascena Mill. with an overview on its phytopharmacological properties.Complement Ther Med. 2017 Oct;34:129-140. doi: 10.1016/j.ctim.2017.08.014. Epub 2017 Aug 25. Complement Ther Med. 2017. PMID: 28917365 Review.
-
Rosa Damascena oil improved sexual function and testosterone in male patients with opium use disorder under methadone maintenance therapy-results from a double-blind, randomized, placebo-controlled clinical trial.Drug Alcohol Depend. 2017 Jul 1;176:117-125. doi: 10.1016/j.drugalcdep.2017.02.008. Epub 2017 Apr 6. Drug Alcohol Depend. 2017. PMID: 28531768 Clinical Trial.
-
The Effect of Topical Rosa damascena (Rose) Oil on Pregnancy-Related Low Back Pain: A Randomized Controlled Clinical Trial.J Evid Based Complementary Altern Med. 2017 Jan;22(1):120-126. doi: 10.1177/2156587216654601. Epub 2016 Jun 22. J Evid Based Complementary Altern Med. 2017. PMID: 27335145 Free PMC article. Clinical Trial.
-
Efficacy of nonprescription doses of ibuprofen for treating migraine headache. a randomized controlled trial.Headache. 2001 Jul-Aug;41(7):665-79. doi: 10.1046/j.1526-4610.2001.041007665.x. Headache. 2001. PMID: 11554954 Clinical Trial.
Cited by
-
Beneficial medicinal effects and material applications of rose.Heliyon. 2023 Dec 10;10(1):e23530. doi: 10.1016/j.heliyon.2023.e23530. eCollection 2024 Jan 15. Heliyon. 2023. PMID: 38169957 Free PMC article. Review.
-
Ginger (Zingiber Officinale Roscoe) ameliorates ethanol-induced cognitive impairment by modulating NMDA and GABA-A receptors in rat hippocampus.Metab Brain Dis. 2024 Jan;39(1):67-76. doi: 10.1007/s11011-023-01301-8. Epub 2023 Nov 15. Metab Brain Dis. 2024. PMID: 37966694
-
Essential Oils as an Alternative Treatment for Migraine Headache: A Systematic Review and Meta-Analysis.Korean J Fam Med. 2024 Jan;45(1):18-26. doi: 10.4082/kjfm.23.0106. Epub 2023 Oct 30. Korean J Fam Med. 2024. PMID: 37899272 Free PMC article.
-
A comprehensive review on clinically proven natural products in the management of nerve pain, with mechanistic insights.Heliyon. 2023 Apr 14;9(5):e15346. doi: 10.1016/j.heliyon.2023.e15346. eCollection 2023 May. Heliyon. 2023. PMID: 37159686 Free PMC article. Review.
-
Evaluation of a Polyherbal Formulation on the Management of Migraine Headaches due to Functional Dyspepsia: A Double-Blind, Randomized, Placebo-Controlled Clinical Trial.Evid Based Complement Alternat Med. 2022 Dec 3;2022:9872933. doi: 10.1155/2022/9872933. eCollection 2022. Evid Based Complement Alternat Med. 2022. PMID: 36510578 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical