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Review
. 2017:18:159-181.
doi: 10.1007/978-3-319-60189-2_8.

Inflammatory Activation of Microglia and Astrocytes in Manganese Neurotoxicity

Ronald B Tjalkens  1   2   3 , Katriana A Popichak  4 , Kelly A Kirkley  5   6
Affiliations
Review

Inflammatory Activation of Microglia and Astrocytes in Manganese Neurotoxicity

Ronald B Tjalkens et al. Adv Neurobiol. 2017.

Abstract

Neurotoxicity due to excessive exposure to manganese (Mn) has been described as early as 1837 (Couper, Br Ann Med Pharm Vital Stat Gen Sci 1:41-42, 1837). Extensive research over the past two decades has revealed that Mn-induced neurological injury involves complex pathophysiological signaling mechanisms between neurons and glial cells. Glial cells are an important target of Mn in the brain, both for sequestration of the metal, as well as for activating inflammatory signaling pathways that damage neurons through overproduction of numerous reactive oxygen and nitrogen species and inflammatory cytokines. Understanding how these pathways are regulated in glial cells during Mn exposure is critical to determining the mechanisms underlying permanent neurological dysfunction stemming from excess exposure. The subject of this review will be to delineate mechanisms by which Mn interacts with glial cells to perturb neuronal function, with a particular emphasis on neuroinflammation and neuroinflammatory signaling between distinct populations of glial cells.

Keywords: Astrogliosis; Glial fibrillary acidic protein (GFAP); Manganism; Parkinson’s disease (PD); Pattern recognition receptors (PRRs).

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References

    1. Alcamo E, et al. Targeted mutation of TNF receptor I rescues the RelA-deficient mouse and reveals a critical role for NF-kappa B in leukocyte recruitment. J Immunol 2001;167:1592–600. - PubMed
    1. Araque A, Carmignoto G, Haydon PG. Dynamic signaling between astrocytes and neurons. Annu Rev Physiol 2001;63:795–813. 10.1146/annurev.physiol.63.1.795. - DOI - PubMed
    1. Aschner M, Aschner JL. Manganese neurotoxicity: cellular effects and blood-brain barrier transport. Neurosci Biobehav Rev 1991;15:333–40. - PubMed
    1. Aschner JL, Aschner M. Nutritional aspects of manganese homeostasis. Mol Asp Med 2005;26:353–62. 10.1016/j.mam.2005.07.003. - DOI - PMC - PubMed
    1. Aschner M, Gannon M, Kimelberg HK. Manganese uptake and efflux in cultured rat astrocytes. J Neurochem 1992;58:730–5. - PubMed

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