Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1987 Sep;84(17):6020-4.
doi: 10.1073/pnas.84.17.6020.

Expression and secretion of type beta transforming growth factor by activated human macrophages

R K Assoian, B E Fleurdelys, H C Stevenson, P J Miller, D K Madtes, E W Raines, R Ross, M B Sporn

Expression and secretion of type beta transforming growth factor by activated human macrophages

R K Assoian et al. Proc Natl Acad Sci U S A. 1987 Sep.

Abstract

Alveolar macrophages activated with concanavalin A and peripheral blood monocytes activated with lipopolysaccharide secrete type beta transforming growth factor (TGF-beta). There is minimal TGF-beta secretion in unactivated monocytes, even though TGF-beta mRNA is expressed in these cells at a level similar to that in activated, lipopolysaccharide-treated cultures. U937 lymphoma cells, which have monocytic characteristics, also express mRNA for TGF-beta. Freshly isolated monocytes, both control and lipopolysaccharide-treated, secrete an acid-labile binding protein that inhibits TGF-beta action. We conclude the following: (i) that expression of TGF-beta mRNA is unrelated to monocyte activation, (ii) that secretion of TGF-beta is induced by monocyte activation, and (iii) that cosecretion of TGF-beta and its monocyte/macrophage-derived binding protein may modulate growth factor action. In contrast, monocytic expression of other growth factor genes, such as the B chain of platelet-derived growth factor, is not constitutive and requires activation.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. J Biophys Biochem Cytol. 1961 Dec;11:677-700 - PubMed
    1. Proc Natl Acad Sci U S A. 1986 Apr;83(8):2438-42 - PubMed
    1. Nature. 1984 Jun 28-Jul 4;309(5971):804-6 - PubMed
    1. Methods Enzymol. 1984;108:242-9 - PubMed
    1. Int J Cancer. 1976 May 15;17(5):565-77 - PubMed

Publication types

LinkOut - more resources