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Observational Study
. 2017 Nov;124(11):1473-1488.
doi: 10.1007/s00702-017-1781-0. Epub 2017 Sep 1.

Near-infrared spectroscopy (NIRS) and vagus somatosensory evoked potentials (VSEP) in the early diagnosis of Alzheimer's disease: rationale, design, methods, and first baseline data of the Vogel study

Thomas Polak  1 , Martin J Herrmann  2 , Laura D Müller  2 , Julia B M Zeller  2 , Andrea Katzorke  2 , Matthias Fischer  2 , Fabian Spielmann  2 , Erik Weinmann  2 , Leif Hommers  2   3   4 , Martin Lauer  2 , Andreas J Fallgatter  5   6 , Jürgen Deckert  2
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Observational Study

Near-infrared spectroscopy (NIRS) and vagus somatosensory evoked potentials (VSEP) in the early diagnosis of Alzheimer's disease: rationale, design, methods, and first baseline data of the Vogel study

Thomas Polak et al. J Neural Transm (Vienna). 2017 Nov.

Abstract

Functional near-infrared spectroscopy (fNIRS) and vagus somatosensory evoked potentials (VSEP) show deviant patterns in subjects with Alzheimer's disease (AD) compared to healthy controls. We now aimed at testing the predictive value of these methods in the early diagnosis of AD. The Vogel study is a prospective, observational, long-term follow-up study with three time points of investigation within 6 years. Residents of the city of Würzburg born between 1936 and 1941 were recruited. Every participant underwent physical, psychiatric, and laboratory examinations, and performed an intense neuropsychological testing as well as VSEP and NIRS according to the published procedures. 604 subjects were included. Mean age of the participants was 73.9 ± 1.55 years. The most frequent pathological physical and laboratory examination results were observed for blood pressure (62%), body weight (54%), HbA1c (16%), cholesterol (42%), and homocysteine (69%). Comprehensive analysis of cognitive testing showed mild cognitive impairment (MCI) in 12.3% of the patients. Concurrent major depression was found in 6.6% of the patients. We observed a high rate of MCI and somatic comorbidity in our cohort. The high rate of vascular risk factors and depressive symptoms, all of which are known risk factors of AD, is consistent with the notion that there are multiple options to prevent or postpone the onset of AD in a geriatric population like the one of the Vogel studies.

Keywords: Alzheimer’s disease; Early diagnosis; Evoked potentials; Near-infrared spectroscopy; Predictive value; Vagus nerve.

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References

    1. Neurobiol Dis. 2014 Feb;62:135-43 - PubMed
    1. Acta Neuropathol. 2011 Sep;122(3):271-83 - PubMed
    1. PLoS One. 2014 Feb 18;9(2):e88854 - PubMed
    1. Alzheimers Dement. 2013 May;9(3):e96-e105 - PubMed
    1. Dement Geriatr Cogn Disord. 1998;9 Suppl 2:20-6 - PubMed

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