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. 2017 Jun 1;28(2):63-69.
doi: 10.1684/ecn.2017.0395.

Characterization of a long isoform of IL-1R8 (TIR8/SIGIRR)

Maria Giovanna Vilia  1 , Marta Tocchetti  1 , Eleonora Fonte  1 , Ilenia Sana  1 , Marta Muzio  1
Affiliations

Characterization of a long isoform of IL-1R8 (TIR8/SIGIRR)

Maria Giovanna Vilia et al. Eur Cytokine Netw. .

Abstract

IL-1R8, also known as SIGIRR or TIR8, is a trans-membrane protein belonging to the IL-1 receptor family. The human gene includes ten exons, and alternative splicing can result in different isoforms. We, herein, characterized a longer isoform of IL-1R8 containing an in-frame additional sequence between the TIR domain and the C-terminal portion of the protein. IL-1R8 Long (IL-1R8L1) mRNA was specifically expressed and regulated in distinct cell lines, in a manner similar to the classic isoform. Overexpression of IL-1R8L1 resulted in the production of a corresponding protein that showed a pattern of cell localization similar to the classic isoform. An antibody directed against an IL-1R8L1 specific peptide, detected this novel isoform in different cell lines and tissues where this protein may complement the anti-inflammatory functions of classic IL-1R8.

Keywords: IL-1R8; SIGIRR; TIR8; Toll-like receptor; interleukin-1 receptor; splicing.

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