Epigenetic changes by DNA methylation in chronic and intermittent hypoxia
- PMID: 28839104
- PMCID: PMC5814703
- DOI: 10.1152/ajplung.00325.2017
Epigenetic changes by DNA methylation in chronic and intermittent hypoxia
Abstract
DNA methylation of cytosine residues is a well-studied epigenetic change, which regulates gene transcription by altering accessibility for transcription factors. Hypoxia is a pervasive stimulus that affects many physiological processes. The circulatory and respiratory systems adapt to chronic sustained hypoxia, such as that encountered during a high-altitude sojourn. Many people living at sea level experience chronic intermittent hypoxia (IH) due to sleep apnea, which leads to cardiovascular and respiratory maladaptation. This article presents a brief update on emerging evidence suggesting that changes in DNA methylation contribute to pathologies caused by chronic IH and potentially mediate adaptations to chronic sustained hypoxia by affecting the hypoxia-inducible factor (HIF) signaling pathway.
Keywords: DNA methyl transferases; antioxidant enzyme; blood pressure; carotid body reflex; redox state.
Copyright © 2017 the American Physiological Society.
Figures
Similar articles
-
Epigenetic regulation of redox state mediates persistent cardiorespiratory abnormalities after long-term intermittent hypoxia.J Physiol. 2017 Jan 1;595(1):63-77. doi: 10.1113/JP272346. Epub 2016 Oct 2. J Physiol. 2017. PMID: 27506145 Free PMC article.
-
DNA methylation in the central and efferent limbs of the chemoreflex requires carotid body neural activity.J Physiol. 2018 Aug;596(15):3087-3100. doi: 10.1113/JP274833. Epub 2018 Jan 4. J Physiol. 2018. PMID: 29148180 Free PMC article.
-
Neural Activation of Molecular Circuitry in Intermittent Hypoxia.Curr Opin Physiol. 2019 Feb;7:9-14. doi: 10.1016/j.cophys.2018.11.003. Epub 2018 Nov 29. Curr Opin Physiol. 2019. PMID: 31544168 Free PMC article.
-
Epigenetics: A Potential Mechanism Involved in the Pathogenesis of Various Adverse Consequences of Obstructive Sleep Apnea.Int J Mol Sci. 2019 Jun 15;20(12):2937. doi: 10.3390/ijms20122937. Int J Mol Sci. 2019. PMID: 31208080 Free PMC article. Review.
-
Cellular mechanisms associated with intermittent hypoxia.Essays Biochem. 2007;43:91-104. doi: 10.1042/BSE0430091. Essays Biochem. 2007. PMID: 17705795 Review.
Cited by
-
Time Domains of Hypoxia Responses and -Omics Insights.Front Physiol. 2022 Aug 8;13:885295. doi: 10.3389/fphys.2022.885295. eCollection 2022. Front Physiol. 2022. PMID: 36035495 Free PMC article. Review.
-
Adaptive cardiorespiratory changes to chronic continuous and intermittent hypoxia.Handb Clin Neurol. 2022;188:103-123. doi: 10.1016/B978-0-323-91534-2.00009-6. Handb Clin Neurol. 2022. PMID: 35965023 Free PMC article. Review.
-
Activation of the High Mobility Group Box 1/Receptor for Advanced Glycation Endproducts /NOD-like Receptor Family Pyrin Domain-Containing 3 Axis Under Chronic Intermittent Hypoxia Induction Promotes the Progression of Atherosclerosis in ApoE-/- Mice.J Am Heart Assoc. 2023 Apr 18;12(8):e024397. doi: 10.1161/JAHA.121.024397. Epub 2023 Apr 7. J Am Heart Assoc. 2023. PMID: 37026550 Free PMC article.
-
Pathophysiological mechanisms and therapeutic approaches in obstructive sleep apnea syndrome.Signal Transduct Target Ther. 2023 May 25;8(1):218. doi: 10.1038/s41392-023-01496-3. Signal Transduct Target Ther. 2023. PMID: 37230968 Free PMC article. Review.
-
Metabolic reprogramming and epigenetic modifications on the path to cancer.Protein Cell. 2022 Dec;13(12):877-919. doi: 10.1007/s13238-021-00846-7. Epub 2021 May 29. Protein Cell. 2022. PMID: 34050894 Free PMC article. Review.
References
-
- Beall CM, Brittenham GM, Strohl KP, Blangero J, Williams-Blangero S, Goldstein MC, Decker MJ, Vargas E, Villena M, Soria R, Alarcon AM, Gonzales C. Hemoglobin concentration of high-altitude Tibetans and Bolivian Aymara. Am J Phys Anthropol 106: 385–400, 1998. doi:10.1002/(SICI)1096-8644(199807)106:3<385::AID-AJPA10>3.0.CO;2-X. - DOI - PubMed
-
- Beall CM, Cavalleri GL, Deng L, Elston RC, Gao Y, Knight J, Li C, Li JC, Liang Y, McCormack M, Montgomery HE, Pan H, Robbins PA, Shianna KV, Tam SC, Tsering N, Veeramah KR, Wang W, Wangdui P, Weale ME, Xu Y, Xu Z, Yang L, Zaman MJ, Zeng C, Zhang L, Zhang X, Zhaxi P, Zheng YT. Natural selection on EPAS1 (HIF2alpha) associated with low hemoglobin concentration in Tibetan highlanders. Proc Natl Acad Sci USA 107: 11459–11464, 2010. doi:10.1073/pnas.1002443107. - DOI - PMC - PubMed
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources