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. 2017 Jul 1;216(suppl_1):S1-S8.
doi: 10.1093/infdis/jix117.

Addressing the Challenges and Opportunities of the Polio Endgame: Lessons for the Future

Manish Patel  1 , Stephen Cochi  1
Affiliations

Addressing the Challenges and Opportunities of the Polio Endgame: Lessons for the Future

Manish Patel et al. J Infect Dis. .

Abstract

The Global Commission for the Certification of the Eradication of Poliomyelitis certified the eradication of type 2 poliovirus in September 2015, making type 2 poliovirus the first human pathogen to be eradicated since smallpox. The eradication of type 2 poliovirus, the absence of detection of type 3 poliovirus worldwide since November 2012, and cornering type 1 poliovirus to only a few geographic areas of 3 countries has enabled implementation of the endgame of polio eradication which calls for a phased withdrawal of oral polio vaccine beginning with the type 2 component, introduction of inactivated poliovirus vaccine, strengthening of routine immunization in countries with extensive polio resources, and initiating activities to transition polio resources, program experience, and lessons learned to other global health initiatives. This supplement focuses on efforts by global partners to successfully launch polio endgame activities to permanently secure and sustain the enormous gains of polio eradication forever.

Keywords: IPV; OPV; endgame; eradication; inactivated poliovirus vaccine; oral poliovirus vaccine; polio; poliovirus.

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Figures

Figure 1.
Figure 1.
The Polio Eradication and Endgame Strategic Plan, 2013–2018. Abbreviations: bOPV, bivalent oral poliovirus vaccine; GPEI, Global Polio Eradication Initiative; IPV, inactivated poliovirus vaccine; OPV, oral poliovirus vaccine; RI, routine immunization; tOPV, trivalent oral poliovirus vaccine; WPV2, type 2 wild poliovirus.
Figure 2.
Figure 2.
Rationale, risks, mitigation strategies, and operational considerations for withdrawal of the type 2 component of oral poliovirus vaccine (OPV2). Abbreviations: AFP, acute flaccid paralysis; bOPV, bivalent oral poliovirus vaccine; cVDPV, type 2 circulating vaccine-derived poliovirus; IPV, inactivated poliovirus vaccine; mOPV, monovalent oral poliovirus vaccine; tOPV, trivalent oral poliovirus vaccine; WPV2, type 2 wild poliovirus.
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