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. 2017 Sep;23(9):1604-1608.
doi: 10.3201/eid2309.170168.

Indication of Cross-Species Transmission of Astrovirus Associated with Encephalitis in Sheep and Cattle

Céline L Boujon, Michel C Koch, Daniel Wüthrich, Simea Werder, Dennis Jakupovic, Rémy Bruggmann, Torsten Seuberlich

Indication of Cross-Species Transmission of Astrovirus Associated with Encephalitis in Sheep and Cattle

Céline L Boujon et al. Emerg Infect Dis. 2017 Sep.

Abstract

We report the identification of a neurotropic astrovirus associated with encephalitis in a sheep. This virus is genetically almost identical to an astrovirus recently described in neurologically diseased cattle. The similarity indicates that astroviruses of the same genotype may cause encephalitis in different species.

Keywords: Astroviridae; astrovirus; cattle; cross-species transmission; enteric infections; meningitis/encephalitis; metagenomics; neurology; ruminants; sheep; viruses; zoonoses.

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Figures

Figure
Figure
Immunohistochemistry (IHC) for ovine astrovirus CH16 in brain tissues (hippocampus) of a sheep (ID 41669) with encephalitis using 2 polyclonal antisera targeted at the putative capsid protein of bovine astrovirus CH15. A) IHC using antiserum against the conserved region of the capsid protein showing positive staining (box at left; box at right shows area at higher magnification); B) negative control. C) IHC using antiserum against the variable regions of the capsid protein n showing positive staining (box at left; box at right shows area at higher magnification); D) negative control. Scale bars indicate 50 μm.
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