Cytology versus HPV testing for cervical cancer screening in the general population
- PMID: 28796882
- PMCID: PMC6483676
- DOI: 10.1002/14651858.CD008587.pub2
Cytology versus HPV testing for cervical cancer screening in the general population
Abstract
Background: Cervical cancer screening has traditionally been based on cervical cytology. Given the aetiological relationship between human papillomavirus (HPV) infection and cervical carcinogenesis, HPV testing has been proposed as an alternative screening test.
Objectives: To determine the diagnostic accuracy of HPV testing for detecting histologically confirmed cervical intraepithelial neoplasias (CIN) of grade 2 or worse (CIN 2+), including adenocarcinoma in situ, in women participating in primary cervical cancer screening; and how it compares to the accuracy of cytological testing (liquid-based and conventional) at various thresholds.
Search methods: We performed a systematic literature search of articles in MEDLINE and Embase (1992 to November 2015) containing quantitative data and handsearched the reference lists of retrieved articles.
Selection criteria: We included comparative test accuracy studies if all women received both HPV testing and cervical cytology followed by verification of the disease status with the reference standard, if positive for at least one screening test. The studies had to include women participating in a cervical cancer screening programme who were not being followed up for previous cytological abnormalities.
Data collection and analysis: We completed a 2 x 2 table with the number of true positives (TP), false positives (FP), true negatives (TN), and false negatives for each screening test (HPV test and cytology) used in each study. We calculated the absolute and relative sensitivities and the specificities of the tests for the detection of CIN 2+ and CIN 3+ at various thresholds and computed sensitivity (TP/(TP + TN) and specificity (TN/ (TN + FP) for each test separately. Relative sensitivity and specificity of one test compared to another test were defined as sensitivity of test-1 over sensitivity of test-2 and specificity of test-1 over specificity of test-2, respectively. To assess bias in the studies, we used the Quality Assessment of Diagnostic test Accuracy Studies (QUADAS) tool. We used a bivariate random-effects model for computing pooled accuracy estimates. This model takes into account the within- and between-study variability and the intrinsic correlation between sensitivity and specificity.
Main results: We included a total of 40 studies in the review, with more than 140,000 women aged between 20 and 70 years old. Many studies were at low risk of bias. There were a sufficient number of included studies with adequate methodology to perform the following test comparisons: hybrid capture 2 (HC2) (1 pg/mL threshold) versus conventional cytology (CC) (atypical squamous cells of undetermined significance (ASCUS)+ and low-grade squamous intraepithelial lesions (LSIL)+ thresholds) or liquid-based cytology (LBC) (ASCUS+ and LSIL+ thresholds), other high-risk HPV tests versus conventional cytology (ASCUS+ and LSIL+ thresholds) or LBC (ASCUS+ and LSIL+ thresholds). For CIN 2+, pooled sensitivity estimates for HC2, CC and LBC (ASCUS+) were 89.9%, 62.5% and 72.9%, respectively, and pooled specificity estimates were 89.9%, 96.6%, and 90.3%, respectively. The results did not differ by age of women (less than or greater than 30 years old), or in studies with verification bias. Accuracy of HC2 was, however, greater in European countries compared to other countries. The results for the sensitivity of the tests were heterogeneous ranging from 52% to 94% for LBC, and 61% to 100% for HC2. Overall, the quality of the evidence for the sensitivity of the tests was moderate, and high for the specificity.The relative sensitivity of HC2 versus CC for CIN 2+ was 1.52 (95% CI: 1.24 to 1.86) and the relative specificity 0.94 (95% CI: 0.92 to 0.96), and versus LBC for CIN 2+ was 1.18 (95% CI: 1.10 to 1.26) and the relative specificity 0.96 (95% CI: 0.95 to 0.97). The relative sensitivity of HC2 versus CC for CIN 3+ was 1.46 (95% CI: 1.12 to 1.91) and the relative specificity 0.95 (95% CI: 0.93 to 0.97). The relative sensitivity of HC2 versus LBC for CIN 3+ was 1.17 (95% CI: 1.07 to 1.28) and the relative specificity 0.96 (95% CI: 0.95 to 0.97).
Authors' conclusions: Whilst HPV tests are less likely to miss cases of CIN 2+ and CIN 3+, these tests do lead to more unnecessary referrals. However, a negative HPV test is more reassuring than a negative cytological test, as the cytological test has a greater chance of being falsely negative, which could lead to delays in receiving the appropriate treatment. Evidence from prospective longitudinal studies is needed to establish the relative clinical implications of these tests.
Conflict of interest statement
Figures
Update of
- doi: 10.1002/14651858.CD008587
Similar articles
-
Human papillomavirus testing versus repeat cytology for triage of minor cytological cervical lesions.Cochrane Database Syst Rev. 2013 Mar 28;2013(3):CD008054. doi: 10.1002/14651858.CD008054.pub2. Cochrane Database Syst Rev. 2013. PMID: 23543559 Free PMC article. Review.
-
Risk of precancer and follow-up management strategies for women with human papillomavirus-negative atypical squamous cells of undetermined significance.Obstet Gynecol. 2007 Jun;109(6):1325-31. doi: 10.1097/01.AOG.0000263461.71732.40. Obstet Gynecol. 2007. PMID: 17540804 Clinical Trial.
-
Screening properties of human papillomavirus testing for predicting cervical intraepithelial neoplasia in atypical squamous cells of undetermined significance and low-grade squamous intraepithelial lesion smears: a prospective study.Ann Diagn Pathol. 2009 Apr;13(2):73-7. doi: 10.1016/j.anndiagpath.2008.12.001. Epub 2009 Feb 5. Ann Diagn Pathol. 2009. PMID: 19302953 Clinical Trial.
-
[Health technology assessment report. Use of liquid-based cytology for cervical cancer precursors screening].Epidemiol Prev. 2012 Sep-Oct;36(5 Suppl 2):e1-e33. Epidemiol Prev. 2012. PMID: 23139163 Review. Italian.
-
Liquid-based cytology and human papillomavirus testing: a pooled analysis using the data from 13 population-based cervical cancer screening studies from China.Gynecol Oncol. 2014 May;133(2):172-9. doi: 10.1016/j.ygyno.2014.03.008. Epub 2014 Mar 11. Gynecol Oncol. 2014. PMID: 24631450
Cited by
-
Dr. George Papanicolaou: The Visionary Who Revolutionized Women's Health.Cureus. 2024 Sep 12;16(9):e69302. doi: 10.7759/cureus.69302. eCollection 2024 Sep. Cureus. 2024. PMID: 39398720 Free PMC article. Review.
-
From barriers to opportunities from COVID-19 pandemic: Stakeholder perspectives on cervical cancer screening programs in LMICs of the Asia-Pacific region.PLOS Glob Public Health. 2024 Oct 4;4(10):e0003768. doi: 10.1371/journal.pgph.0003768. eCollection 2024. PLOS Glob Public Health. 2024. PMID: 39365795 Free PMC article.
-
Comparison of cervical cancer screening models based on Pap and HPV tests in Tbilisi, Georgia.Cent Eur J Public Health. 2024 Sep;32(3):166-172. doi: 10.21101/cejph.a8014. Cent Eur J Public Health. 2024. PMID: 39352091
-
Looking Back, Moving Forward: Challenges and Opportunities for Global Cervical Cancer Prevention and Control.Viruses. 2024 Aug 25;16(9):1357. doi: 10.3390/v16091357. Viruses. 2024. PMID: 39339834 Free PMC article. Review.
-
Self-Screening for Cervical Cancer Offered through a Digital Platform in a Region of British Columbia with Lower Screening Rates.Curr Oncol. 2024 Sep 13;31(9):5399-5411. doi: 10.3390/curroncol31090399. Curr Oncol. 2024. PMID: 39330027 Free PMC article.
References
References to studies included in this review
Agorastos 2005 {published data only}
-
- Agorastos T, Dinas K, Lloveras B, Sanjose S, Kornegay JR, Bonti H, et al. Human papillomavirus testing for primary screening in women at low risk of developing cervical cancer. The Greek experience. Gynecologic Oncology 2005;96:714‐20. - PubMed
Agorastos 2015 {published data only}
Belinson 2003 {published data only}
-
- Belinson JL, Qiao YL, Pretorius RG, Zhang WH, Rong SD, Huang MN, et al. Shanxi Province cervical cancer screening study II: self‐sampling for high‐risk human papillomavirus compared to direct sampling for human papillomavirus and liquid based cervical cytology. International Journal of Gynecological Cancer 2003;13:819‐26. - PubMed
Belinson 2010 {published data only}
Bigras 2005 {published data only}
Blumenthal 2001 {published data only}
-
- Blumenthal PD, Gaffikin L, Chirenje ZM, McGrath J, Womack S, Shah K. Adjunctive testing for cervical cancer in low resource settings with visual inspection, HPV, and the Pap smear. International Journal of Gynaecology and Obstetrics 2001;72:47‐53. - PubMed
Cardenas‐Turanzas 2008 {published data only}
Castle 2011a {published data only}
-
- Castle PE, Stoler MH, Wright TC Jr, Sharma A, Wright TL, Behrens CM. Performance of carcinogenic human papillomavirus (HPV) testing and HPV16 or HPV18 genotyping for cervical cancer screening of women aged 25 years and older: a sub analysis of the ATHENA study. Lancet Oncology 2011;12:880–90. - PubMed
Clavel 2001 {published data only}
Cuzick 1995 {published data only}
-
- Cuzick J, Szarewski A, Terry G, Ho L, Hanby A, Maddox P, et al. Human papillomavirus testing in primary cervical screening. Lancet 1995;345:1533‐6. - PubMed
Cuzick 1999 {published data only}
Cuzick 2003 {published data only}
-
- Cuzick J, Swarewski A, Cubie H, Hulman G, Kitchener H, Luesley D, et al. Management of women who test positive for high‐risk types of human papillomavirus: the HART study. The Lancet 2003;362:1871‐6. - PubMed
de Cremoux 2003 {published data only}
-
- Cremoux P, Coste J, Sastre‐Garau X, Thioux M, Bouillac C, Labbe S, et al. Efficiency of the hybrid capture 2 HPV DNA test in cervical cancer screening. American Journal of Clinical Pathology 2003;120:492‐9. - PubMed
Depuydt 2011 {published data only}
-
- Depuydt CE, Makar AP, Ruymbeke MJ, Benoy IH, Vereecken AJ, Bogers JJ. BD‐ProExC as adjunct molecular marker for improved detection of CIN2+ after HPV primary screening. Cancer Epidemiol Biomarkers & Prevention 2011;20:628‐37. - PubMed
Ferreccio 2013 {published data only}
-
- Ferreccio C, Barriga MI, Lagos M, Ibanez C, Poggi H, Gonzalez F, et al. Screening trial of human papillomavirus for early detection of cervical cancer in Santiago, Chile. International Journal of Cancer 2013;132:916–23. - PubMed
Gravitt 2010 {published data only}
Hovland 2010 {published data only}
Iftner 2015 {published data only}
-
- Iftner T, Becker S, Neis KJ, Castanon A, Iftner A, Holz B, et al. Head‐to‐head comparison of the RNA‐based Aptima human papillomavirus (HPV) assay and the DNA‐based hybrid capture 2 HPV test in a routine screening population of women aged 30 to 60 years in Germany. Journal of Clinical Microbiology 2015;53:2509‐16. - PMC - PubMed
Kulasingam 2002 {published data only}
-
- Kulasingam SL, Hughes JP, Kiviat NB, Mao C, Weiss NS, Kuypers JM, et al. Evaluation of human papillomavirus testing in primary screening for cervical abnormalities: comparison of sensitivity, specificity, and frequency of referral. JAMA 2002;288:1749‐57. - PubMed
Labani 2014 {published data only}
-
- Labani S, Asthana S, Sodhani P, Gupta S, Bhambhani S, Pooja B, et al. Care HPV cervical cancer screening demonstration in a rural population of North India. European Journal of Obstetrics & Gynecology and Reproductive Biology 2014;176:75‐9. - PubMed
Li 2009 {published data only}
Mahmud 2012 {published data only}
-
- Mahmud SM, Sangwa‐Lugoma G, Nasr SH, Kayembe PK, Tozin RR, Drouin P, et al. Comparison of human papillomavirus testing and cytology for cervical cancer screening in a primary health care setting in the Democratic Republic of the Congo. Gynecologic Oncology 2012;124:286‐91. - PubMed
McAdam 2010a {published data only}
McAdam 2010b {published data only}
Monsonego 2011 {published data only}
-
- Monsonego J, Hudgens MG, Zerat L, Zerat J‐C, Syrjanen K, Halfon P, et al. Evaluation of oncogenic human papillomavirus RNA and DNA tests with liquid‐based cytology in primary cervical cancer screening: the FASE study. International Journal of Cancer 2011;129:691–701. - PubMed
Moy 2010 {published data only}
-
- Moy LM, Zhao F‐H, Li L‐Y, Ma J‐F, Zhang Q‐M, Chen F, et al. Human papillomavirus testing and cervical cytology in primary screening for cervical cancer among women in rural China: comparison of sensitivity, specificity, and frequency of referral. International Journal of Cancer 2010;127:646‐56. - PubMed
Naucler 2009 {published data only}
-
- Naucler P, Ryd W, Tornberg S, Strand A, Wadell G, Elfgren K, et al. Efficacy of HPV DNA testing with cytology triage and/or repeat HPV DNA testing in primary cervical cancer screening. Journal of the National Cancer Institute 2009;101:88‐99. - PubMed
Nieves 2013 {published data only}
-
- Nieves L, Enerson CL, Belinson S, Brainard J, Chiesa‐Vottero A, Nagore N, et al. Primary cervical cancer screening and triage using an mRNA human papillomavirus assay and visual inspection. International Journal of Gynecological Cancer 2013;23:513‐8. - PubMed
Pan 2003 {published data only}
-
- Pan Q, Belinson JL, Li L, Pretorius RG, Qiao YL, Zhang WH, et al. A thin layer, liquid‐based Pap test for mass screening in an area of China with a high incidence of cervical carcinoma. A cross‐sectional, comparative study. Acta Cytologica 2003;47:45‐50. - PubMed
Paraskevaidis 2001 {published data only}
-
- Paraskevaidis E, Malamou‐Mitsi V, Koliopoulos G, Pappa L, Lolis E, Georgiou I, et al. Expanded cytological referral criteria for colposcopy in cervical screening: comparison with human papillomavirus testing. Gynecologic Oncology 2001;82:355‐9. - PubMed
Petry 2003 {published data only}
Qiao 2008 {published data only}
-
- Qiao YI, Sellors JW, Eder PS, Bao Y‐P, Lim JM, Zhao F‐H, et al. A new HPV DNA test for cervical‐cancer screening in developing regions: a cross‐sectional study of clinical accuracy in rural China. Lancet Oncology 2008;9:929‐36. - PubMed
Ronco 2006 {published data only}
-
- Ronco G, Segnan N, Giorgi‐Rossi P, Zappa M, Casadei GP, Carozzi F, et al. Human papillomavirus testing and liquid based cytology: results at recruitment from the new technologies for cervical cancer randomized controlled trial. Journal of the National Cancer Institute 2006;98:765‐74. - PubMed
Salmeron 2003 {published data only}
-
- Salmeron J, Lazcano‐Ponce E, Lorincz A, Hernandez M, Hernandez P, Leyva A, et al. Comparison of HPV‐based assays with Papanicolaou smears for cervical cancer screening in Morelos State, Mexico. Cancer Causes & Control 2003;14:505‐12. - PubMed
Sankaranarayanan 2004a {published data only}
-
- Sankaranarayanan R, Chatterji R, Shastri SS, Wesley RS, Basu P, Mahe C, et al. Accuracy of human papillomavirus testing in primary screening of cervical neoplasia: results from a multicenter study in India. International Journal of Cancer 2004;112:341‐7. - PubMed
Sarian 2005 {published data only}
-
- Sarian LO, Derchain SF, Naud P, Roteli‐Martins C, Longatto‐Filho A, Tatti S, et al. Evaluation of visual inspection with acetic acid (VIA), Lugol's Iodine (VILI), cervical cytology and HPV testing as cervical screening tools in Latin America. This report refers to partial results from the LAMS study. Journal of Medical Screening 2005;12:142‐9. - PubMed
Schneider 2000 {published data only}
-
- Schneider A, Hoyer H, Lotz B, Leistritza S, Kuhne‐Heid R, Nindl I, et al. Screening for high‐grade cervical intra‐epithelial neoplasia and cancer by testing for high‐risk HPV, routine cytology or colposcopy. International Journal of Cancer 2000;89:529‐34. - PubMed
Shipitsyna 2011 {published data only}
-
- Shipitsyna E, Zolotoverkhaya E, Kuevda D, Nasonova V, Romanyuk T, Khachaturyan A, et al. Prevalence of high‐risk human papillomavirus types and cervical squamous intraepithelial lesions in women over 30 years of age in St. Petersburg, Russia. Cancer Epidemiology 2011;35:160‐4. - PubMed
Syrjanen 2002 {published and unpublished data}
-
- Syrjaenen S, Shabalova I. Human papillomavirus testing and conventional Pap smear cytology as optional screening tools of women at different risks for cervical cancer in the countries of the former Soviet Union. Journal of Lower Genital Tract Disease 2002;6:97‐110. - PubMed
Wu 2010 {published data only}
-
- Wu R, Belinson SE, Du H, Na W, Qu X, Wu R, et al. Human papillomavirus messenger RNA assay for cervical cancer screening: the Shenzhen Cervical Cancer Screening Trial I. International Journal of Gynecological Cancer 2010;20:1411‐4. - PubMed
References to studies excluded from this review
An 2003 {published data only}
-
- An HJ, Cho NH, Lee SY, Kim IH, Lee C, Mun MS, et al. Correlation of cervical carcinoma and precancerous lesions with human papillomavirus (HPV) genotypes detected with the HPV DNA Chip Microarray Method. Cancer 2003;97:1672‐80. - PubMed
Belinson 2001 {published data only}
-
- Belinson J, Qiao YL, Pretorius R, Zhang WH, Elson P, Li L, et al. Shanxi province cervical cancer screening study: a cross‐sectional comparative trial of multiple techniques to detect cervical neoplasia. Gynecologic Oncology 2001;83:439‐44. - PubMed
Belinson 2010a {published data only}
-
- Belinson JL, Hu S, Niyazi M, Pretorius RG, Wang H, Wen C, et al. Prevalence of type‐specific human papillomavirus in endocervical, upper and lower vaginal, perineal and vaginal self‐collected specimens: implications for vaginal self‐collection. International Journal of Cancer 2010;127:1151‐7. - PubMed
Belinson 2011 {published data only}
-
- Belinson JL, Wu R, Belinson SE, Qu X, Yang B, Du H, et al. A population‐based clinical trial comparing endocervical high‐risk HPV testing using hybrid capture 2 and Cervista From the SHENCCAST II Study. American Journal of Clinical Pathology 2011;135:790‐5. - PubMed
Belinson 2012 {published data only}
-
- Belinson JL, Du H, Yang B, Wu R, Belinson SE, Qu X, et al. Improved sensitivity of vaginal self‐collection and high‐risk human papillomavirus testing. International Journal of Cancer 2012;15:1855‐60. - PubMed
Benevolo 2011a {published data only}
-
- Benevolo M, Terrenato I, Mottolese M, Marandino F, Carosi M, Rollo F, et al. Diagnostic and prognostic validity of the human papillomavirus E6/E7 mRNA test in cervical cytological samples of HC2‐positive patients. Cancer Causes & Control 2011;22:869–75. - PubMed
Benevolo 2011b {published data only}
Benoy 2011 {published data only}
-
- Benoy IH, Vanden Broeck D, Ruymbeke MJ, Sahebali S, Arbyn M, Bogers JJ, et al. Prior knowledge of HPV status improves detection of CIN2+ by cytology screening. American Journal of Obstetrics and Gynecology 2011;205:569.e1‐7. - PubMed
Castle 2010 {published data only}
Chao 2010 {published data only}
-
- Chao A, Chang C‐J, Lai C‐H, Chao F‐Y, Hsu Y‐H, Chou H‐H, et al. Incidence and outcome of acquisition of human papillomavirus infection in women with normal cytology—a population‐based cohort study from Taiwan. International Journal of Cancer 2010;126:191–8. - PubMed
Coquillard 2011 {published data only}
-
- Coquillard G, Palao B, Patterson BK. Quantification of intracellular HPV E6/E7 mRNA expression increases the specificity and positive predictive value of cervical cancer screening compared to HPV DNA. Gynecologic Oncology 2011;120:89‐93. - PubMed
Costa 2000 {published data only}
-
- Costa S, Sideri M, Syrjanen K, Terzano P, Nuzzo M, Simone P, et al. Combined Pap smear, cervicography and HPV DNA testing in the detection of cervical intraepithelial neoplasia and cancer. Acta Cytologica 2000;44:310‐18. - PubMed
Coste 2003 {published data only}
Dai 2006 {published data only}
de Andrade 2011 {published data only}
Denny 2000 {published data only}
-
- Denny L, Kuhn L, Pollack A, Wainwright H, Wright TC. Evaluation of alternative methods of cervical cancer screening for resource‐poor settings. Cancer 2000;89:826‐33. - PubMed
Depuydt 2012 {published data only}
-
- Depuydt CE, Benoy IH, Beert JF, Criel AM, Bogers JJ, Arbyn M. Clinical validation of a type‐specific real‐time quantitative human papillomavirus PCR against the performance of hybrid capture 2 for the purpose of cervical cancer screening. Journal of Clinical Microbiology 2012;50:4073‐7. - PMC - PubMed
De Vuyst 2005 {published data only}
-
- Vuyst H, Claeys P, Njiru S, Muchiri L, Steyaert S, Sutter P, et al. Comparison of Pap smear, visual inspection with acetic acid, human papillomavirus DNA‐PCR testing and cervicography. International Journal of Gynecology and Obstetrics 2005;89:120‐6. - PubMed
Diamantopoulou 2013 {published data only}
-
- Diamantopoulou S, Spathis A, Chranioti A, Anninos D, Stamataki M, Chrelias C, et al. Liquid based cytology and HPV DNA testing in a Greek population compared to colposcopy and histology. Clinical and Experimental Obstetrics & Gynecology 2013;40:131‐6. - PubMed
Fereccio 2003 {published data only}
-
- Ferreccio C, Bratti MC, Sherman ME, Herrero R, Wacholder S, Hildesheim A, et al. A comparison of single and combined visual, cytologic and virologic tests as screening strategies in a region at high risk of cervical cancer. Cancer Epidemiology Biomarkers and Prevention 2003;12:815‐23. - PubMed
Huang 2010 {published data only}
-
- Huang M‐Z, Huang S, Li D‐Q, Nie X‐M, Li H‐B, Jiang X‐M. The study of the combination detection of HPV‐DNA and p16INK4a in cervical lesions. Medical Oncology 2010;28 Suppl 1:S547‐52. - PubMed
Idelevich 2011 {published data only}
-
- Idelevich P, Kristt D, Schechter E, Lew S, Elkeles A, Terkieltaub D, et al. Screening for cervical neoplasia: a community‐based trial comparing Pap staining, human papilloma virus testing, and the new bi‐functional Cell Detect stain. Diagnostic Cytopathology 2011;40:1054‐61. - PubMed
Junyangdikul 2013 {published data only}
-
- Junyangdikul P, Tanchotsrinon W, Chansaenroj J, Nilyaimit P, Lursinsap C, Poovorawan Y. Clinical prediction based on HPV DNA testing by hybrid capture 2 (HC2) in combination with Liquid‐based Cytology (LBC). Asian Pacific Journal of Cancer Prevention 2013;14:903‐7. - PubMed
Katki 2011 {published data only}
Kelesidis 2011 {published data only}
-
- Kelesidis T, Aish L, Steller MA, Aish IS, Shen J, Foukas P, et al. Human papillomavirus (HPV) detection using in situ hybridization in histologic samples: correlations with cytologic changes and polymerase chain reaction HPV detection. American Journal of Clinical Pathology 2011;136:119‐27. - PMC - PubMed
Kim 2013 {published data only}
-
- Kim JH, Kim IW, Kim YW, Park DC, Kim YW, Lee KH, et al. Comparison of single‐, double‐ and triple‐combined testing, including Pap test, HPV DNA test and cervicography, as screening methods for the detection of uterine cervical cancer. Oncology Reports 2013;29:1645‐51. - PubMed
Kitchener 2011 {published data only}
-
- Kitchener HC, Gilham C, Sargent A, Bailey A, Albrow R, Roberts C, et al. A comparison of HPV DNA testing and liquid based cytology over three rounds of primary cervical screening: extended follow up in the ARTISTIC trial. European Journal of Cancer 2011;47:864‐71. - PubMed
Kuhn 2000 {published data only}
-
- Kuhn L, Denny L, Pollack A, Lorincz A, Richart RM, Wright TC. Human papillomavirus DNA testing for cervical cancer screening in low‐resource settings. Journal of the National Cancer Institute 2000;92:818‐25. - PubMed
Li 2010a {published data only}
-
- Li C, Wu M, Wang J, Zhang S, Zhu L, Pan J, et al. A population‐based study on the risks of cervical lesion and human papillomavirus infection among women in Beijing, People's Republic of China. Cancer Epidemiology, Biomarkers & Prevention 2010;19:2655‐64. - PubMed
Li 2010b {published data only}
-
- Li Y, Ye F, Lu W‐G, Zeng W‐J, Wei L‐H, Xie X. Detection of human telomerase RNA gene in cervical cancer and precancerous lesions comparison with cytological and human papillomavirus DNA test findings. International Journal of Gynecological Cancer 2010;20:631‐7. - PubMed
Longatto‐Filho 2012 {published data only}
-
- Longatto‐Filho A, Naud P, Derchain SF, Roteli‐Martins C, Tatti S, Hammes LS, et al. Performance characteristics of Pap test, VIA, VILI, HR‐HPV testing, cervicography, and colposcopy in diagnosis of significant cervical pathology. Virchows Archiv 2012;460:577‐85. - PubMed
Ma 2010 {published data only}
Masumoto 2003 {published data only}
Mesher 2010 {published data only}
Monsonego 2012 {published data only}
-
- Monsonego J, Hudgens MG, Zerat L, Zerat JC, Syrjänen K, Smith JS. Risk assessment and clinical impact of liquid‐based cytology, oncogenic human papillomavirus (HPV) DNA and mRNA testing in primary cervical cancer screening (the FASE study). Gynecologic Oncology 2012;125:175‐80. - PubMed
Nieminen 2004 {published data only}
-
- Nieminen P, Vuorma S, Viikki M, Hakama M, Anttila A. Comparison of HPV test versus conventional and automation‐assisted Pap screening as potential screening tools for preventing cervical cancer. BJOG 2004;111:842‐8. - PubMed
Oh 2001 {published data only}
-
- Oh YL, Shin KJ, Han J, Kim DS. Significance of high‐risk human papillomavirus detection by polymerase chain reaction in primary cervical cancer screening. Cytopathology 2001;12:75‐83. - PubMed
Ozcan ES 2011 {published data only}
-
- Özcan ES, Tașkın S, Ortaç F. High‐risk human papilloma virus prevalence and its relation with abnormal cervical cytology among Turkish women. Journal of Obstetrics and Gynaecology 2011;31:656‐8. - PubMed
Quincy 2012 {published data only}
-
- Quincy BL, Turbow DJ, Dabinett LN, Dillingham R, Monroe S. Diagnostic accuracy of self‐collected human papillomavirus specimens as a primary screen for cervical cancer. Journal of Obstetrics and Gynaecology 2012;32:795‐9. - PubMed
Ratnam 2000 {published data only}
-
- Ratnam S, France EL, Ferenczy A. Human papillomavirus testing for primary screening of cervical cancer precursors. Cancer Epidemiology Biomarkers and Prevention 2000;9:945‐51. - PubMed
Riethmuller 1999 {published data only}
-
- Riethmuller D, Gay C, Bertrand X, Bettinger D, Schaal JP, Carbillet JP, et al. Genital human papillomavirus infection among women recruited for routine cervical cancer screening or for colposcopy determined by hybrid capture II and polymerase chain reaction. Diagnostic Molecular Pathology 1999;8:157‐64. - PubMed
Rijkaart 2012b {published data only}
Sankaranarayanan 2004b {published data only}
-
- Sankaranarayanan R, Thara S, Sharma A, Roy C, Shastri S, Mahé C, et al. Accuracy of conventional cytology: results from a multicentre screening study in India. Journal of Medical Screening 2004;11:77‐84. - PubMed
Sankaranarayanan 2005 {published data only}
-
- Sankaranarayanan R, Nene BM, Dinshaw KA, Mahe C, Jayant K, Shastri SS, et al. A cluster randomized controlled trial of visual, cytology and human papillomavirus screening for cancer of the cervix in rural India. International Journal of Cancer 2005;116:617‐23. - PubMed
Schiffman 2000 {published data only}
-
- Schiffman M, Herrero R, Hildesheim A, Sherman ME, Bratti M, Wacholder S, et al. HPV DNA screening in cervical cancer screening. Results from women in a high‐risk province of Costa‐Rica. JAMA 2000;283:87‐93. - PubMed
Shastri 2005 {published data only}
Sherman 2003 {published data only}
-
- Sherman ME, Lorincz AT, Scott D, Wacholder S, Castle PE, Glass AG, et al. Baseline cytology, human papillomavirus testing, and risk for cervical neoplasia: a 10‐year cohort analysis. Journal of the National Cancer Institute 2003;95:46‐52. - PubMed
Siriaunkgul 2014 {published data only}
-
- Siriaunkgul S, Settakorn J, Sukpan K, Srisomboon J, Suprasert P, Kasatpibal N, et al. Population‐based cervical cancer screening using high‐risk HPV DNA test and liquid‐based cytology in northern Thailand. Asian Pacific Journal of Cancer Prevention 2014;15:6837‐42. - PubMed
Surabhi 2011 {published data only}
Wang 2013 {published data only}
-
- Wang JL, Yang YZ, Dong WW, Sun J, Tao HT, Li RX, et al. Application of human papillomavirus in screening for cervical cancer and precancerous lesions. Asian Pacific Journal of Cancer Prevention 2013;14:2979‐82. - PubMed
Womack 2000 {published data only}
-
- Womack SD, Chirenje ZM, Blumenthal PD, Gaffikin L, McGrath JA, Chipato T, et al. Evaluation of a human papillomavirus assay in cervical screening in Zimbabwe. BJOG 2000;107:33‐8. - PubMed
Zhao 2010 {published data only}
Additional references
Anttila 2004
Arbyn 2004
-
- Arbyn M, Buntinx F, Ranst M, Paraskevaidis E, Martin‐Hirsch P, Dillner J. Cytologic versus virologic triage of women with equivocal Pap smears: a meta‐analysis of the accuracy to detect high‐grade intraepithelial neoplasia. Journal of the National Cancer Institute 2004; Vol. 96:280‐93. - PubMed
Arbyn 2006
-
- Arbyn M, Sasieni P, Meijer CJ, Clavel C, Koliopoulos G, Dillner J. Chapter 9: Clinical applications of HPV testing: a summary of meta‐analyses. Vaccine 2006;24 Suppl 3:78‐89. - PubMed
Arbyn 2008
-
- Arbyn M, Sankaranarayanan R, Muwonge R, Keita N, Dolo A, Mbalawa CG, et al. Pooled analysis of the accuracy of five cervical cancer screening tests assessed in eleven studies in Africa and India. International Journal of Cancer 2008;123:153‐60. - PubMed
Arbyn 2009
-
- Arbyn M, Raifu AO, Bray F, Weiderpass E, Anttila A. Trends of cervical cancer mortality in the member states of the European Union. European Journal of Cancer 2009;45(15):2640‐8. - PubMed
Arbyn 2009a
Arbyn 2010
Arbyn 2011
-
- Arbyn M, Castellsagué X, Sanjosé S, Bruni L, Saraiya M, Bray F, et al. Worldwide burden of cervical cancer in 2008. Annals of Oncology 2011;12:2675‐86. - PubMed
Arbyn 2012
-
- Arbyn M, Ronco G, Anttila A, Meijer CJ, Poljak M, Ogilvie G, et al. Evidence regarding human papillomavirus testing in secondary prevention of cervical cancer. Vaccine 2012;30 Suppl 5:F88‐99. - PubMed
Bosch 2002
Breitenecker 2004
-
- Breitenecker G, Dinges HP, Regitnig P, Wiener H, Vutuc C. Cytopathology in Austria. Cytopathology 2004;15:113‐8. - PubMed
Castle 2011b
-
- Castle PE, Stoler MH, Wright TC Jr, Sharma A, Wright TL, Behrens CM. Performance of carcinogenic human papillomavirus (HPV) testing and HPV16 or HPV18 genotyping for cervical cancer screening of women aged 25 years and older: a subanalysis of the ATHENA study. Lancet Oncology 2011;12:880‐90. - PubMed
Chan 1999
-
- Chan AB, Fox JD. NASBA and other transcription‐based amplification methods for research and diagnostic microbiology. Review Medical Microbiology 1999;10:184‐96.
Chu 2006
-
- Chu H, Cole SR. Bivariate meta‐analysis of sensitivity and specificity with sparse data: a generalized linear mixed model approach. Journal of Clinical Epidemiology 2006;59(12):1331‐2. - PubMed
Dijkstra 2013
-
- Dijkstra MG, Niekerk D, Rijkaart DC, Kemenade FJ, Heideman DA, Snijders PJ, et al. Primary hrHPV DNA testing in cervical cancer screening: how to manage screen‐positive women? A POBASCAM trial substudy. Cancer Epidemiology, Biomarkers & Prevention 2014;23:55‐63. - PubMed
Dilner 1999
-
- Dilner J. The serological response to papillomaviruses. Seminars in Cancer Biology 1999;9:423‐30. - PubMed
IARC 2005
-
- International Agency for research on Cancer. Cervix Cancer Screening: IARC Handbooks of Cancer Prevention. Vol. 10, Lyon: IARC, 2005.
IARC 2007
-
- IARC working group on the evaluation of carcinogenic risks to humans. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Volume 90: Human Papilloma viruses. Lyon, France: IARC Press, 2007.
Jeronimo 2006
-
- Jeronimo J, Schiffman M. Colposcopy at a crossroads. American Journal of Obstetrics and Gynecology 2006;195:349‐53. - PubMed
Jordan 2008
-
- Jordan J, Arbyn M, Martin‐Hirsch P, Schenck U, Baldauf JJ, Silva D, et al. European guidelines for quality assurance in cervical cancer screening: recommendations for clinical management of abnormal cervical cytology, part 1. Cytopathology 2008;19:342‐54. - PubMed
Kjaer 2004
-
- Kjaer S. Long term predictive value of HPV testing (the Danish prospective cohort study). 21st International Human Papillomavirus Conference. Mexico City, Feb 20‐26, 2004:Abstract 339.
Laara 1987
-
- Laara E, Day NE, Hakarna M. Trends in mortality from cervical cancer in the Nordic countries: association with organised screening programmes. Lancet 1987;1:1247‐9. - PubMed
Mandelblatt 2002
-
- Mandelblatt JS, Lawrence WF, Womack SM, Jacobson D, Yi B, Hwang YT, et al. Benefits and costs of using HPV testing to screen for cervical cancer. JAMA 2002;287:2372‐81. - PubMed
McCaffery 2004
-
- McCaffery K, Waller J, Forrest S, Cadman L, Szarewski A, Wardle J. Testing positive for human papillomavirus in routine cervical screening: examination of psychosocial impact. BJOG 2004;111:1437‐43. - PubMed
McCredie 2008
-
- McCredie MR, Sharples KJ, Paul C, Baranyai J, Medley G, Jones RW, et al. Natural history of cervical neoplasia and risk of invasive cancer in women with cervical intraepithelial neoplasia 3: a retrospective cohort study. Lancet Oncology 2008;9:425‐34. - PubMed
McIndoe 1984
-
- McIndoe WA, McLean MR, Jones RW, Mullins PR. The invasive potential of carcinoma in situ of the cervix. Obstetrics and Gynecology 1984;64:451‐8. - PubMed
Meera 2002
-
- Meera E, Gales C, Cochand‐Priollet B, Cartier I, Cremoux P, Vacher‐Lavenu MC, et al. Cost of screening for cancerous and precancerous lesions of the cervix. Diagnostic Cytopathology 2002;27:251‐7. - PubMed
Moher 2009
NHSCSP 2004
-
- Luesley D, Leeson S. NHSCSP Publication No. 20. Colposcopy and Programme Management. Guidelines for the NHS Cervical Screening Programme. Sheffield: NHS Cancer Screening Programmes, 2004.
Papanicolaou 1941
-
- Papanicolaou GN, Trauat HF. The diagnostic value of vaginal smears in carcinoma of the uterus. American Journal of Obstetrics and Gynecology 1941;42:193‐206.
Poljak 2012
-
- Poljak M, Cuzick J, Kocjan BJ, Iftner T, Dillner J, Arbyn M. Nucleic acid tests for the detection of alpha human papillomaviruses. Vaccine 2012;30(Suppl 5):F100‐6. - PubMed
Quinn 1999
Reitsma 2005
-
- Reitsma JB, Glas AS, Rutjes AWS, Scholten RJPM, Bossuyt PM, Zwinderman AH. Bivariate analysis of sensitivity and specificity produces informative summary measures in diagnostic reviews. Journal of Clinical Epidemiology 2005;58(10):982‐90. - PubMed
Reitsma 2009
-
- Reitsma JB, Rutjes AWS, Whiting P, Vlassov VV, Leeflang MMG, Deeks JJ. Chapter 9: Assessing methodological quality. In: Deeks JJ, Bossuyt PM, Gatsonis C (editors), Cochrane Handbook for Systematic Reviews of Diagnostic Test Accuracy Version 1.0.0. The Cochrane Collaboration, 2009. Available from: srdta.cochrane.org/.
RevMan 2014 [Computer program]
-
- Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager 5 (RevMan 5). Copenhagen: Nordic Cochrane Centre, The Cochrane Collaboration, 2014.
Rijkaart 2012a
-
- Rijkaart DC, Berkhof J, Kemenade FJ, Coupe VM, Hesselink AT, Rozendaal L, Heideman DA, Verheijen RH, Bulk S, Verweij WM, Snijders PJ, Meijer CJ. Evaluation of 14 triage strategies for HPV DNA‐positive women in population‐based cervical screening. Int J Cancer 2012;130:602‐10. - PubMed
Ronco 2014
-
- Ronco G, Dillner J, Elfström KM, Tunesi S, Snijders PJ, Arbyn M, Kitchener H, Segnan N, Gilham C, Giorgi‐Rossi P, Berkhof J, Peto J, Meijer CJ, International HPV sc. Efficacy of HPV‐based screening for prevention of invasive cervical cancer: follow‐up of four European randomised controlled trials. Lancet 2014;383:524‐32.. - PubMed
SAS 9.4 [Computer program]
-
- SAS Institute Inc. SAS Institute Inc. SAS/ACCESS® 9.4 Interface to ADABAS. Reference. Cary, NC, 2013.
Saslow 2012
-
- Saslow D, Solomon D, Lawson HW, Killackey M, Kulasingam SL, Cain J, Garcia FA, Moriarty AT, Waxman AG, Wilbur DC, Wentzensen N, Downs LS Jr, Spitzer M, Moscicki AB, Franco EL, Stoler MH, Schiffman M, Castle PE, Myers ER, American Cancer Society, American Society for Colposcopy and Cervical Pathology, American Society for Clinical Pathology. American Cancer Society, American Society for Colposcopy and Cervical Pathology, and American Society for Clinical Pathology screening guidelines for the prevention and early detection of cervical cancer. Am J Clin Pathol. 2012;137:516‐42. - PubMed
Schatzkin 1987
-
- Schatzkin A, Connor RJ, Taylor PR, Bunnag B. Comparing new and old screening tests when a reference procedure cannot be performed on all screenees. Example of automated cytometry for early detection of cervical cancer. American Journal of Epidemiology 1897;125:672‐8. - PubMed
Schiffman 2007
-
- Schiffman M, Castle PE, Jeronimo J, Rodriguez AC, Wacholder S. Human papillomavirus and cervical cancer. Lancet 2007;370:890‐907. - PubMed
Sigurdsson 1999
-
- Sigurdsson K. The Icelandic and Nordic cervical screening programs: trends in incidence and mortality rates through1995. Acta Obstetricia et Gynecologica Scandinavica 1999;78:478‐85. - PubMed
Solomon 2002
-
- Solomon D, Davey D, Kurman R, Moriarty A, O'Connor D, Prey M, et al. The 2001 Bethesda System: terminology for reporting results of cervical cytology. JAMA 2002;287:2114‐9. - PubMed
Spence 2007
-
- Spence AR, Goggin P, Franco EL. Process of care failures in invasive cervical cancers: A systematic review and meta‐analysis. Preventive Medicine 2007;45:93‐106. - PubMed
STATA 14 [Computer program]
-
- StataCorp. StataCorp. Stata Statistical Software: Release 14. College Station, TX. StataCorp LP, 2015.
Stoler 2001
-
- Stoler MH, Schiffman M. Atypical squamous cells of undetermined significance‐low grade squamous intraepithelial lesion triage study (ALTS) group. Interobserver reproducibility of cervical cytologic and histologic interpretations: realistic estimates from the ASCUS‐LSIL triage study. JAMA 2001;285:1500‐5. - PubMed
Takwoingi 2010
-
- Twakoingi Y, Deeks JJ. MetaDAS: A SAS macro for meta‐analysis of diagnostic accuracy studies. Quick reference and worked example.. Available from methods.cochrane.org/sdt/software‐meta‐analysis‐dta‐studies. 1.3 2010.
Walboomers 1999
-
- Walboomers JMM, Jacobs MV, Manos MM, Bosch X, Kummer A, Shah KV, et al. Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. Journal of Pathology 1999;189:12‐9. - PubMed
Wentzensen 2015
Whiting 2003
Wilson 1968
-
- Wilson JMG, Jungner G. Principles and practice of screening for disease. Public Health Papers. Vol. 34, Geneva: World Health Organization, 1968.
Wright 2006
-
- Wright TC Jr, Massad LS, Dunton CJ, Spitzer M, Wilkinson EJ, Solomon D. 2006 consensus guidelines for the management of women with abnormal cervical cancer screening tests. American Journal of Obstetrics and Gynecology 2007;197:346‐55. - PubMed
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials