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Review
. 2017 Nov;37(6):1350-1372.
doi: 10.1002/med.21460. Epub 2017 Jul 31.

Recent advances in uveal melanoma treatment

Beatriz Álvarez-Rodríguez  1 , Alfonso Latorre  1 , Christian Posch  2   3 , Álvaro Somoza  1
Affiliations
Review

Recent advances in uveal melanoma treatment

Beatriz Álvarez-Rodríguez et al. Med Res Rev. 2017 Nov.

Abstract

Uveal melanoma (UM) is the most common primary intraocular malignancy in adults. Recent advances in the understanding of molecular characteristics helped to determine which tumors are most likely to progress. About 50% of patients carrying genetic alterations such as chromosomal aberrations and mutations are at significant risk for metastatic disease of which the majority will succumb to UM within few months. Currently, there is no effective treatment for metastatic uveal melanoma, and we hope this review will encourage researchers and clinicians to work to find a better standard of care. In this article we provide a comprehensive overview of the molecular framework of UM, highlighting the most common mutations involved in this kind of cancer. It also covers the most recent treatments from basic research to clinical trials, including small molecules, nucleic acids or immunotherapy, among others. It is intended to serve as a key reference for clinicians and researchers working in this field.

Keywords: MAPK pathway; PI3K pathway; cancer; melanoma; uveal melanoma.

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